Title:
METHOD FOR CHEMICAL SYNTHESIS OF PSEUDOMONAS AERUGINOSA O11 SEROTYPE O ANTIGEN OLIGOSACCHARIDE
Document Type and Number:
WIPO Patent Application WO/2020/125307
Kind Code:
A1
Abstract:
Disclosed is a method for constructing a Pseudomonas aeruginosa O11 serotype O antigen oligosaccharide using a D-glucose block, a L-fucosamine block and a D-fucosamine block, wherein the D-glucose block or the L-fucosamine block is connected to the D-fucosamine block via a 1,2-α-cis-glycosidic bond, and the D-glucose block is connected to the L-fucosamine block via a 1,2-β-trans-glycosidic bond, wherein the construction of the 1,2-α-cis-glycosidic bond is performed in a mixed solvent, the mixed solvent comprising two or more of dichloromethane, ethyl ether and thiophene.
Inventors:
YIN JIAN (CN)
HU JING (CN)
LIU ZHONGHUA (CN)
QIN CHUNJUN (CN)
HU JING (CN)
LIU ZHONGHUA (CN)
QIN CHUNJUN (CN)
Application Number:
PCT/CN2019/119584
Publication Date:
June 25, 2020
Filing Date:
November 20, 2019
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C07H15/04; A61P31/04; C07H1/00; C07K2/00
Foreign References:
| CN109627270A | 2019-04-16 | |||
| CN108558961A | 2018-09-21 | |||
| CN107709343A | 2018-02-16 |
Other References:
D'AMBRA, A. J. ET AL.: "Analysis by the Reductive-cleavage Method of a Polysaccharide Containing 2-acetamido-2，6-dideoxy-D and -L-galactopyranosyl Residues", CARBOHYDRATE RESEARCH, vol. 251, 3 January 1994 (1994-01-03), XP026661031, ISSN: 0008-6215, DOI: 20200108151350Y
QIN, CHUNJUN ET AL.: "Total Synthesis of a Densely Functionalized Plesiomonas Shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 8, 29 January 2018 (2018-01-29), XP055627596, ISSN: 1520-5126, DOI: 20200108152211Y
QIN, CHUNJUN ET AL.: "Total Synthesis of a Densely Functionalized Plesiomonas Shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 8, 29 January 2018 (2018-01-29), XP055627596, ISSN: 1520-5126, DOI: 20200108152211Y
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF:
Previous Patent: INFORMATION INPUT METHOD AND DEVICE
Next Patent: BULK ACOUSTIC RESONATOR AND PREPARATION METHOD THEREFOR
Next Patent: BULK ACOUSTIC RESONATOR AND PREPARATION METHOD THEREFOR