Title:
METHOD FOR CLINICALLY AND PATHOLOGICALLY MONITORING ALZHEIMER'S DISEASE THROUGH CONCENTRATION OF AMYLOIDBETA IN PLASMA
Document Type and Number:
WIPO Patent Application WO/2016/175625
Kind Code:
A1
Abstract:
The present invention relates to a method for quantifying Aβ in plasma by treating the plasma with MPP and/or TCEP, and a method for diagnosing, using the quantifying method, whether or not clinical cognitive deterioration and pathological Aβ accumulation occur. Through cut-off values of measured values measured by the method for quantifying Aβ according to the present invention, it is possible to identify normal, MCI and AD subjects and determine whether or not accumulation of Aβ in the brain occurs, and it is possible to predict progression to AD.
Inventors:
MOOK INHEE (KR)
PARK JONG-CHAN (KR)
CHO HYUN JIN (KR)
PARK JONG-CHAN (KR)
CHO HYUN JIN (KR)
Application Number:
PCT/KR2016/004572
Publication Date:
November 03, 2016
Filing Date:
April 30, 2016
Export Citation:
Assignee:
UNIV SEOUL NAT R & DB FOUND (KR)
International Classes:
G01N33/68; A61B5/15; G01N1/10
Domestic Patent References:
| WO2014164519A1 | 2014-10-09 |
Foreign References:
| US20110243957A1 | 2011-10-06 |
Other References:
CHO ET AL.: "Correlations of Amyloid-ß Concentrations between CSF and Plasma in Acute Alzheimer Mouse Model", SCIENTIFIC REPORTS, vol. 4, 2014, pages 1 - 4, XP055325956
MARTI-FABREGAS ET AL.: "Prognostic Value of Plasma ß -amyloid Levels in Patients with Acute Intracerebral Hemorrhage", STROKE, vol. 45, 2014, pages 413 - 417
PESARESI ET AL.: "Plasma Levels of Beta-amyloid (1-42) in Alzheimer's Disease and Mild Cognitive Impairment", NEUROBIOLOGY OF AGING, vol. 27, 2006, pages 904 - 905, XP024993220
MARTI-FABREGAS ET AL.: "Prognostic Value of Plasma ß -amyloid Levels in Patients with Acute Intracerebral Hemorrhage", STROKE, vol. 45, 2014, pages 413 - 417
PESARESI ET AL.: "Plasma Levels of Beta-amyloid (1-42) in Alzheimer's Disease and Mild Cognitive Impairment", NEUROBIOLOGY OF AGING, vol. 27, 2006, pages 904 - 905, XP024993220
Attorney, Agent or Firm:
LEE, JONG SEUNG (KR)
이종승 (KR)
이종승 (KR)
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