Title:
A METHOD AND COMPOSITION FOR ENABLING PASSAGE THROUGH THE BLOOD-BRAIN BARRIER
Document Type and Number:
WIPO Patent Application WO1998022132
Kind Code:
A1
Abstract:
A pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier comprising the agent ACHE-I4 readthrough (SEQ ID No:1) splice variant or the I4 peptide (SEQ ID No:2) and analogues of each thereof and a pharmaceutically acceptable carrier is disclosed. Alternatively, the pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier can comprise the agents adrenaline, atropine, dopamine and/or an adrenergic combination and a pharmaceutically acceptable carrier. The composition can comprise at least two of the agents. The composition of the present invention can optionally include the compound to be transported across the blood-brain barrier. Alternatively, the compound can be co-administered (simultaneously) with the composition or can be administered at some point during the biologically effective period of the action of the composition. The present invention provides a method for administering a compound to the CNS of an animal by subjecting the animal to a stress-mimicking agent or treatment. This agent or treatment facilitates disruption of the blood-brain barrier. During the period that the BBB is opened or disrupted a compound can be administered such that the compound is enabled to pass through the disrupted BBB into the CNS.
Inventors:
SOREQ HERMONA (IL)
FRIEDMAN ALON (IL)
SEIDMAN SHLOMO (IL)
KAUFER DANIELA (IL)
FRIEDMAN ALON (IL)
SEIDMAN SHLOMO (IL)
KAUFER DANIELA (IL)
Application Number:
PCT/US1997/021696
Publication Date:
May 28, 1998
Filing Date:
November 20, 1997
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
KOHN KENNETH I (US)
SOREQ HERMONA (IL)
FRIEDMAN ALON (IL)
SEIDMAN SHLOMO (IL)
KAUFER DANIELA (IL)
KOHN KENNETH I (US)
SOREQ HERMONA (IL)
FRIEDMAN ALON (IL)
SEIDMAN SHLOMO (IL)
KAUFER DANIELA (IL)
International Classes:
A61K31/135; A61K31/137; A61K31/138; A61K31/46; A61K38/00; A61K45/06; A61K38/16; A61K38/46; A61P43/00; C12P19/34; (IPC1-7): A61K38/46; A61K31/135; A61K31/46
Domestic Patent References:
| WO1995023158A1 | 1995-08-31 |
Foreign References:
| EP0414568A2 | 1991-02-27 | |||
| EP0364584A1 | 1990-04-25 |
Other References:
FRIEDMAN, ALON ET AL: "Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response", NAT. MED. (N. Y.) (1996), 2(12), 1382-1385, XP002065074
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