Title:
METHOD AND COMPOSITION FOR GENERATING PROGRAMMED CELL DEATH RESISTANT ALGAL CELLS
Document Type and Number:
WIPO Patent Application WO/2011/056886
Kind Code:
A3
Abstract:
The present invention provides transgenic algal cells resistant to programmed cell death (PCD) and methods and compositions useful in generating such cells. Specifically, the invention utilizes expression of one or more mammalian anti-apoptotic genes in algal cells to promote resistance to PCD, which is useful for stress tolerance and increased cell viability and biomass production during cultivation.
Inventors:
BETENBAUGH MICHAEL J (US)
OYLER GEORGE A (US)
ROSENBERG JULIAN N (US)
OYLER GEORGE A (US)
ROSENBERG JULIAN N (US)
Application Number:
PCT/US2010/055317
Publication Date:
September 15, 2011
Filing Date:
November 03, 2010
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
BETENBAUGH MICHAEL J (US)
OYLER GEORGE A (US)
ROSENBERG JULIAN N (US)
BETENBAUGH MICHAEL J (US)
OYLER GEORGE A (US)
ROSENBERG JULIAN N (US)
International Classes:
C12N1/13; A01H13/00; C12N15/12; C12N15/79; C12R1/89
Foreign References:
| US20030064510A1 | 2003-04-03 | |||
| US6015687A | 2000-01-18 |
Other References:
DICKMAN, M. B. ET AL.: "Abrogation of disease development in plants expressing animal antiapoptotic genes", PNAS, vol. 98, no. 12, 29 May 2001 (2001-05-29), pages 6957 - 6962, XP002341916, DOI: doi:10.1073/pnas.091108998
YANG, Z. ET AL.: "Expression of human soluble TRAIL in Chlamydomonas reinhard tii chloroplast", CHINESE SCIENCE BULLETIN, vol. 51, no. 14, 30 July 2006 (2006-07-30), pages 1703 - 1709
MOHARIKAR, S. ET AL.: "Apoptotic-like cell death pathway is induced in unicellular chlorophyte Chlamydomonas reinhardt ii (Chlorophyceae) cells following UV irradiation: detection and functional analyses", JOURNAL OF PHYCOLOGY., vol. 42, no. 2, April 2006 (2006-04-01), pages 423 - 433
YANG, Z. ET AL.: "Expression of human soluble TRAIL in Chlamydomonas reinhard tii chloroplast", CHINESE SCIENCE BULLETIN, vol. 51, no. 14, 30 July 2006 (2006-07-30), pages 1703 - 1709
MOHARIKAR, S. ET AL.: "Apoptotic-like cell death pathway is induced in unicellular chlorophyte Chlamydomonas reinhardt ii (Chlorophyceae) cells following UV irradiation: detection and functional analyses", JOURNAL OF PHYCOLOGY., vol. 42, no. 2, April 2006 (2006-04-01), pages 423 - 433
Attorney, Agent or Firm:
HAILE, Lisa, A. (4365 Executive Drive Suite 110, San Diego CA, US)
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