Title:
METHOD AND COMPOSITION FOR PREDICTING THE POSTSURGICAL RECURRENCE IN PATIENT SUFFERING FROM PULMONARY ADENOCARCINOMA
Document Type and Number:
WIPO Patent Application WO/2009/084740
Kind Code:
A1
Abstract:
Disclosed is a method for predicting the recurrence of pulmonary adenocarcinoma after
surgically removing lung cancer in a patient suffering from pulmonary adenocarcinoma
by using a specific gene set. Also disclosed is a composition for use in the method.
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Inventors:
TAKAHASHI TAKASHI (JP)
TOMIDA SHUTA (JP)
TAKEUCHI TOSHIYUKI (JP)
YATABE YASUSHI (JP)
MITSUDOMI TETSUYA (JP)
TOMIDA SHUTA (JP)
TAKEUCHI TOSHIYUKI (JP)
YATABE YASUSHI (JP)
MITSUDOMI TETSUYA (JP)
Application Number:
PCT/JP2008/073982
Publication Date:
July 09, 2009
Filing Date:
December 26, 2008
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
ONCOMICS CO LTD (JP)
AICHI PREFECTURE (JP)
TAKAHASHI TAKASHI (JP)
TOMIDA SHUTA (JP)
TAKEUCHI TOSHIYUKI (JP)
YATABE YASUSHI (JP)
MITSUDOMI TETSUYA (JP)
ONCOMICS CO LTD (JP)
AICHI PREFECTURE (JP)
TAKAHASHI TAKASHI (JP)
TOMIDA SHUTA (JP)
TAKEUCHI TOSHIYUKI (JP)
YATABE YASUSHI (JP)
MITSUDOMI TETSUYA (JP)
International Classes:
C12Q1/68; C12M1/00; C12N15/09; G01N33/574
Domestic Patent References:
| WO2007043418A1 | 2007-04-19 | |||
| WO2006110264A2 | 2006-10-19 |
Foreign References:
| JP2007135466A | 2007-06-07 | |||
| JP2007263896A | 2007-10-11 |
Other References:
BEER, D. G. ET AL.: "Gene-expression profiles predict survival of patients with lung adenocarcinoma", NATURE MEDICINE, vol. 8, no. 8, 2002, pages 816 - 824
YANAGISAWA, K. ET AL.: "A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer", J. NATL. CANCER INST., vol. 99, no. 11, June 2007 (2007-06-01), pages 858 - 867, XP002545290
GOLUB, T. R. ET AL.: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, vol. 286, 1999, pages 531 - 537, XP002207658, DOI: doi:10.1126/science.286.5439.531
LARSEN, J. E. ET AL.: "Gene expression signature predicts recurrence in lung adenocarcinoma", CLIN. CANCER RES., vol. 13, no. 10, May 2007 (2007-05-01), pages 2946 - 2954, XP008123438, DOI: doi:10.1158/1078-0432.CCR-06-2525
MOLINARO, A. M. ET AL.: "Prediction error estimation: a comparison of resampling methods", BIOINFORMATICS, vol. 21, no. 15, 2005, pages 3301 - 3307
AMBROISE, C. ET AL.: "Selection bias in gene extraction on the basis of microarray gene-expression data", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 10, 2002, pages 6562 - 6566
SIMON, R. ET AL.: "Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification", J. NATL. CANCER INST., vol. 95, no. 1, 2003, pages 14 - 18, XP002493056
YANAGISAWA, K. ET AL.: "A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer", J. NATL. CANCER INST., vol. 99, no. 11, June 2007 (2007-06-01), pages 858 - 867, XP002545290
GOLUB, T. R. ET AL.: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, vol. 286, 1999, pages 531 - 537, XP002207658, DOI: doi:10.1126/science.286.5439.531
LARSEN, J. E. ET AL.: "Gene expression signature predicts recurrence in lung adenocarcinoma", CLIN. CANCER RES., vol. 13, no. 10, May 2007 (2007-05-01), pages 2946 - 2954, XP008123438, DOI: doi:10.1158/1078-0432.CCR-06-2525
MOLINARO, A. M. ET AL.: "Prediction error estimation: a comparison of resampling methods", BIOINFORMATICS, vol. 21, no. 15, 2005, pages 3301 - 3307
AMBROISE, C. ET AL.: "Selection bias in gene extraction on the basis of microarray gene-expression data", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 10, 2002, pages 6562 - 6566
SIMON, R. ET AL.: "Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification", J. NATL. CANCER INST., vol. 95, no. 1, 2003, pages 14 - 18, XP002493056
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chome,Minato-k, Tokyo 01, JP)
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