METHOD AND COMPOSITION FOR PREVENTING OR TREATING MYOPIA

Title:

METHOD AND COMPOSITION FOR PREVENTING OR TREATING MYOPIA

Document Type and Number:

WIPO Patent Application WO/2023/149420

Kind Code:

A1

Abstract:

The present disclosure relates to a method for preventing or treating myopia and a composition to be used in this method. The present inventors found that VEGF deficiency induces loss of the choroidal capillary plate and choroidal thinning to thereby cause myopia of the eye. To prevent or treat myopia, therefore, provided are a method and a composition for delivering VEGF or a VEGF agonist to the choroid to retain the choroid. Retaining of the choroid by maintaining the expression, secretion and reception of VEGF is effective in preventing or treating myopia.

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Inventors:

TSUBOTA KAZUO (JP)
KURIHARA TOSHIHIDE (JP)
JEONG HEONK (JP)
ZHANG YAN (JP)
MORI KIWAKO (JP)

Application Number:

PCT/JP2023/003017

Publication Date:

August 10, 2023

Filing Date:

January 31, 2023

Export Citation:

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Assignee:

TSUBOTA LAB INC (JP)

International Classes:

A61K45/00; A61K9/06; A61K9/08; A61K31/7088; A61K35/12; A61K38/02; A61P27/10

Domestic Patent References:

WO2020130038A1

2020-06-25

Foreign References:

JP2019189614A	2019-10-31
JP2016522249A	2016-07-28

Other References:

MARITA FELDKAEMPER; FRANK SCHAEFFEL; LENA FUCHS: "Vascular endothelial growth Factor A, C, D and Vascular Endothelial Growth Factor Receptor 1, 2, 3 mRNA Expression in the Chicken Retina, RPE and Choroid.", INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE., vol. 54, no. 15, 1 January 2013 (2013-01-01), pages 5171, XP009547978
WEI CHEN, HUI SONG, SHIYONG XIE, QUANHONG HAN, XIN TANG, YANHUA CHU: "Correlation of Macular Choroidal Thickness with Concentrations of Aqueous Vascular Endothelial Growth Factor in High Myopia", CURRENT EYE RESEARCH, INFORMA HEALTHCARE USA, US, vol. 40, no. 3, 1 March 2015 (2015-03-01), US , pages 307 - 313, XP009548428, ISSN: 0271-3683, DOI: 10.3109/02713683.2014.973043

Attorney, Agent or Firm:

WATANABE Shinichi (JP)

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