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Title:
METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2003090691
Kind Code:
A3
Abstract:
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

Inventors:
BIRKUS GABRIEL (US)
CHEN JAMES M (US)
CHEN XIAOWU (US)
CIHLAR TOMAS (US)
EISENBERG EUGENE J (US)
HATADA MARCOS (US)
HE GONG-XIN (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
MCDERMOTT MARTIN J (US)
SWAMINATHAN SUNDARAMOORTHI (US)
Application Number:
US0312943W
Publication Date:
February 09, 2006
Filing Date:
April 25, 2003
Export Citation:
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Assignee:
GILEAD SCIENCES, INC.
BIRKUS, GABRIEL
CHEN, JAMES, M.
CHEN, XIAOWU
CIHLAR, TOMAS
EISENBERG, EUGENE, J.
HATADA, MARCOS
HE, GONG-XIN
KIM, CHOUNG, U.
LEE, WILLIAM, A.
MCDERMOTT, MARTIN, J.
SWAMINATHAN, SUNDARAMOORTHI
International Classes:
C12N9/99; A61K31/4155; A61K31/66; A61K31/665; A61K31/675; A61P31/18; A61P43/00; C07D213/75; C07D213/85; C07D231/12; C07D231/20; C07D233/42; C07D239/48; C07D239/80; C07D243/04; C07D265/18; C07D307/68; C07D401/06; C07D403/06; C07D471/14; C07D491/04; C07F9/02; C07F9/38; C07F9/40; C07F9/44; C07F9/58; C07F9/62; C07F9/645; C07F9/6506; C07F9/6509; C07F9/6512; C07F9/653; C07F9/6533; C07F9/655; C07F9/6558; C07F9/6561; C07F9/6584; C12N9/16; C12Q1/18; C12Q1/37; C12Q1/44; C12Q1/70; G01N33/04; G01N33/50; C07F; (IPC1-7): C12Q1/34
Foreign References:
US20020119443A12002-08-29
Other References:
LEE ET AL: "In vivo and in vitro characterization of GS 7340, an isopropylalaninyl phyl ester prodrug of Tenofovir: selective intracellular activation of GS 7340 leads to preferential distribution in lymphatic tissues.", 9TH CONFERENCE OF RETROVIRUSES AND OPPORTUNISTIC INFECTIONS., February 2002 (2002-02-01), pages 1, XP008101031
HOLY A.: "Phosphonomethoxyalkyl analogs of Nucleotides.", CURRENT PHARMACEUTICAL DESIGN., vol. 9, 2003, pages 2567 - 2592, XP008058387
GULICK R M.: "New Antiretroviral drugs.", CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES., vol. 9, 2003, pages 186 - 193, XP002261652
ALEXANDER ET AL: "Prodrugs of Analogs of Nucleic acid components.", COLLECT CZECH CHEM COMMUN., vol. 59, 1994, pages 2127 - 2165, XP008063115
See also references of EP 1575486A4
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