METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS

Title:

METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2005064008

Kind Code:

A9

Abstract:

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

Inventors:

ARIMILLI MURTY N (US)
BECKER MARK M (US)
BIRKUS GABRIEL (US)
BRYANT CLIFFORD (US)
CHEN JAMES M (US)
CHEN XIAOWU (US)
CIHLAR TOMAS (US)
DASTGAH AZAR (US)
EISENBERG EUGENE J (US)
FARDIS MARIA (US)
HATADA MARCOS (US)
HE GONG-XIN (US)
JIN HAOLUN (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
LIN KUEI-YING (US)
LIU HONGTAO (US)
MACKMAN RICHARD L (US)
MCDERMOTT MARTIN J (US)
MITCHELL MICHAEL L (US)
NELSON PETER H (US)
PYUN HYUNG-JUNG (US)
ROWE TANISHA D (US)
SPARACINO MARK (US)
SWAMINATHAN SUNDARAMOORTHI (US)
TARIO JAMES D (US)
WANG JIANYING (US)
WILLIAMS MATTHEW A (US)
XU LIANHONG (US)
YANG ZHENG-YU (US)
YU RICHARD H (US)
ZHANG JIANCUN (US)
ZHANG LIJUN (US)

Application Number:

PCT/US2004/042991

Publication Date:

September 28, 2006

Filing Date:

December 22, 2004

Export Citation:

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Assignee:

GILEAD SCIENCES INC (US)
ARIMILLI MURTY N (US)
BECKER MARK M (US)
BIRKUS GABRIEL (US)
BRYANT CLIFFORD (US)
CHEN JAMES M (US)
CHEN XIAOWU (US)
CIHLAR TOMAS (US)
DASTGAH AZAR (US)
EISENBERG EUGENE J (US)
FARDIS MARIA (US)
HATADA MARCOS (US)
HE GONG-XIN (US)
JIN HAOLUN (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
LIN KUEI-YING (US)
LIU HONGTAO (US)
MACKMAN RICHARD L (US)
MCDERMOTT MARTIN J (US)
MITCHELL MICHAEL L (US)
NELSON PETER H (US)
PYUN HYUNG-JUNG (US)
ROWE TANISHA D (US)
SPARACINO MARK (US)
SWAMINATHAN SUNDARAMOORTHI (US)
TARIO JAMES D (US)
WANG JIANYING (US)
WILLIAMS MATTHEW A (US)
XU LIANHONG (US)
YANG ZHENG-YU (US)
YU RICHARD H (US)
ZHANG JIANCUN (US)
ZHANG LIJUN (US)

International Classes:

C12N9/99; C12Q1/44; A61K31/4155; A61K31/66; A61K31/665; A61K31/675; A61P31/18; A61P43/00; C07D213/75; C07D213/85; C07D231/12; C07D231/20; C07D233/42; C07D239/48; C07D239/80; C07D243/04; C07D265/18; C07D307/68; C07D401/06; C07D403/06; C07D471/14; C07D491/04; C07F9/02; C07F9/38; C07F9/40; C07F9/44; C07F9/58; C07F9/62; C07F9/645; C07F9/6506; C07F9/6509; C07F9/6512; C07F9/653; C07F9/6533; C07F9/655; C07F9/6558; C07F9/6561; C07F9/6584; C12N9/16; C12Q1/18; C12Q1/37; C12Q1/70; G01N33/04; G01N33/50; C07F

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