Title:
METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF MALARIA INFECTIONS
Document Type and Number:
WIPO Patent Application WO2006055623
Kind Code:
A3
Abstract:
Isolated proteins and nucleic acid sequence encoding such protein that interacts with a red blood cell to be invaded by a malaria parasite and link with a component of the actin-myosin based machinery of the malaria parasite are provided. In addition methods for identifying agents which inhibit the function of these proteins as chemotherapeutic and/or immunologic agents for treatment and prevention of malaria infections are provided. Compositions for treatment and prevention of malaria infections and methods for preventing and treating malaria infections are also provided.
Inventors:
BERGMAN LAWRENCE W (US)
VAIDYA AKHIL B (US)
VAIDYA AKHIL B (US)
Application Number:
PCT/US2005/041509
Publication Date:
September 08, 2006
Filing Date:
November 17, 2005
Export Citation:
Assignee:
UNIV DREXEL (US)
BERGMAN LAWRENCE W (US)
VAIDYA AKHIL B (US)
BERGMAN LAWRENCE W (US)
VAIDYA AKHIL B (US)
International Classes:
C07K1/00; A61K39/00; A61K39/015; C07K2/00
Foreign References:
| US6090611A | 2000-07-18 |
Other References:
BERGMAN V. ET AL.: "A merozoite protein that interacts with the actin-myosin motor via aldolase", EXPER. PARASITOL., vol. 105, 2003, pages 30
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