Title:
METHOD FOR CONDUCTING NON-INVASIVE EARLY DETECTION OF COLON CANCER AND/OR OF COLON CANCER PRECURSOR CELLS
Document Type and Number:
WIPO Patent Application WO2005030788
Kind Code:
A3
Abstract:
The invention relates to a method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells, by using primers with which mutation analyses can be carried out in selected regions of genes APC, K-ras, beta -catenin and B-raf. The invention also relates to a kit containing said primers, and to the use of these primers and of the kit for analyzing mutations, particularly for conducting the early detection of colon cancer and/or of colon cancer precursory cells.
Inventors:
STEINBERG PABLO (DE)
SCHOLTKA BETTINA (DE)
SCHOLTKA BETTINA (DE)
Application Number:
PCT/DE2004/002161
Publication Date:
June 16, 2005
Filing Date:
September 23, 2004
Export Citation:
Assignee:
UNIV POTSDAM (DE)
STEINBERG PABLO (DE)
SCHOLTKA BETTINA (DE)
STEINBERG PABLO (DE)
SCHOLTKA BETTINA (DE)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68
Foreign References:
| US6586177B1 | 2003-07-01 |
Other References:
SALAHSHOR SIMA ET AL: "Colorectal cancer with and without microsatellite instability involves different genes", GENES CHROMOSOMES AND CANCER, vol. 26, no. 3, November 1999 (1999-11-01), pages 247 - 252, XP002323208, ISSN: 1045-2257
RAJAGOPALAN H ET AL: "RAF/RAS oncogenes and mismatch-repair status", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 418, 20 August 2002 (2002-08-20), pages 934, XP002270683, ISSN: 0028-0836
DAVIES H ET AL: "MUTATIONS OF THE BRAF GENE IN HUMAN CANCER", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 417, no. 6892, 27 June 2002 (2002-06-27), pages 949 - 954, XP001188240, ISSN: 0028-0836
YUEN S T ET AL: "Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 62, no. 22, 15 November 2002 (2002-11-15), pages 6451 - 6455, XP002984266, ISSN: 0008-5472
PRIX LOTHAR ET AL: "Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool", CLINICAL CHEMISTRY, vol. 48, no. 3, March 2002 (2002-03-01), pages 428 - 435, XP002323209, ISSN: 0009-9147
DONG SEUNG MYUNG ET AL: "Detecting colorectal cancer in stool with the use of multiple genetic targets", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 93, no. 11, 6 June 2001 (2001-06-06), pages 858 - 865, XP002323210, ISSN: 0027-8874
RAJAGOPALAN H ET AL: "RAF/RAS oncogenes and mismatch-repair status", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 418, 20 August 2002 (2002-08-20), pages 934, XP002270683, ISSN: 0028-0836
DAVIES H ET AL: "MUTATIONS OF THE BRAF GENE IN HUMAN CANCER", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 417, no. 6892, 27 June 2002 (2002-06-27), pages 949 - 954, XP001188240, ISSN: 0028-0836
YUEN S T ET AL: "Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 62, no. 22, 15 November 2002 (2002-11-15), pages 6451 - 6455, XP002984266, ISSN: 0008-5472
PRIX LOTHAR ET AL: "Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool", CLINICAL CHEMISTRY, vol. 48, no. 3, March 2002 (2002-03-01), pages 428 - 435, XP002323209, ISSN: 0009-9147
DONG SEUNG MYUNG ET AL: "Detecting colorectal cancer in stool with the use of multiple genetic targets", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 93, no. 11, 6 June 2001 (2001-06-06), pages 858 - 865, XP002323210, ISSN: 0027-8874
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