Title:
METHOD FOR CONDUCTING SOLID PHASE SYNTHESIS OF MOLECULE LIBRARIES USING COMBINATORIAL SEALING MATRICES
Document Type and Number:
WIPO Patent Application WO2002087754
Kind Code:
A3
Abstract:
The invention relates to a method for producing molecule libraries at predetermined locations on a substrate surface by means of sequential chemical reactions involving the use of combinatorial sealing matrices. The topological structures applied to the sealing matrices cover individual areas of the substrate surface in a defined order thereby preventing different partial areas of the substrate surface from undergoing chemical conversions. Several sealing matrices having different topological relief structures can be used in a number of reaction cycles for the synthesis of molecule libraries consisting of complex chemical compounds. The sealing matrices are made of an elastic material such as polydimethylsiloxane. The synthesis involves the use of simple and highly optimized standard methods and standard chemicals of the solid phase synthesis. The reaction rate is accelerated by carrying out the reaction steps in a microfluidic flow-through system. The inventive method can be used for easily and rapidly producing molecule libraries in the microarray format.
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Inventors:
BERNARD ANDRE (DE)
Application Number:
PCT/EP2002/004668
Publication Date:
October 30, 2003
Filing Date:
April 26, 2002
Export Citation:
Assignee:
LIFEBITS AG (DE)
BERNARD ANDRE (DE)
BERNARD ANDRE (DE)
International Classes:
B01J19/00; C07B61/00; C07K1/04; C40B40/06; C40B40/10; C40B40/12; C40B50/14; C40B60/14; (IPC1-7): B01J19/00; C07K1/04; C07H21/00
Domestic Patent References:
| WO1998036827A1 | 1998-08-27 | |||
| WO1999067024A1 | 1999-12-29 |
Foreign References:
| EP0916396A2 | 1999-05-19 |
Other References:
DATABASE WPI Section Ch Week 200103, Derwent World Patents Index; Class B04, AN 2001-025170, XP002230357
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