Title:
METHOD FOR CONSTRUCTING FUNCTIONAL NUCLEIC ACID MOLECULE, AND NUCLEIC ACID COMBINATION TO BE USED IN SAID METHOD
Document Type and Number:
WIPO Patent Application WO/2013/129663
Kind Code:
A1
Abstract:
A method for constructing a functional nucleic acid molecule comprising one or two nucleic acid chain(s), wherein the functional nucleic acid molecule comprising one or two nucleic acid chain(s) is formed by: introducing two or more fragments, in which a pair of functional groups which bond to one another by a chemical reaction are attached to corresponding ends, into a cell; and bonding the fragments to one another by reacting the functional groups with one another inside the cell.
Inventors:
ABE HIROSHI (JP)
ITO YOSHIHIRO (JP)
MARUYAMA HIDETO (JP)
ITO YOSHIHIRO (JP)
MARUYAMA HIDETO (JP)
Application Number:
PCT/JP2013/055732
Publication Date:
September 06, 2013
Filing Date:
March 01, 2013
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C12N15/113; C12N15/09; C40B40/02
Foreign References:
| JP2008259453A | 2008-10-30 | |||
| JP2007521247A | 2007-08-02 | |||
| JP2001514485A | 2001-09-11 | |||
| JP2000510847A | 2000-08-22 |
Other References:
KONDO, Y. ET AL.: "Multiple chemical ligation under thermal cycle", NUCLEIC ACIDS SYMP. SER., no. 51, 2007, pages 353 - 354, XP055164976
ABE, H. ET AL.: "Rapid DNA chemical ligation for amplification of RNA and DNA signal", BIOCONJUG. CHEM., vol. 19, 2008, pages 327 - 333, XP055164981
UDA, M. ET AL.: "Synthesis of dumbbell-shaped nanocircular RNAs for improvement of permeability and stability", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 89 SHUNKI NENKAI KOEN YOKOSHU II, 2009, pages 1521, XP008174518
UDA, M. ET AL.: "Development of modified dumbbell-shaped RNA with cell-penetrating function for RNA interference", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 90 SHUNKI NENKAI KOEN YOKOSHU III, 2010, pages 785, XP008174517
RYAN J TAFT; KEN C PANG; TIMOTHY R MERCER; MARCEL DINGER; JOHN S MATTICK, J PATHOL., vol. 220, 2010, pages 126 - 139
FIRE A; XU S; MONTGOMERY M; KOSTAS S; DRIVER S; MELLO C, NATURE, vol. 391, 1998, pages 806 - 11
SAYDA M. ELBASHIR; JAVIER MARTINEZ; AGNIESZKA PATKANIOWSKA; WINFRIED LENDECKEL; THOMAS TUSCHL, EMBO J., vol. 20, 2001, pages 6877 - 6888
JOHN C. BURNETT; JOHN J. ROSSI; KATRIN TIEMANN, BIOTECHNOL. J., vol. 6, 2011, pages 1130 - 1146
BIOCONJUGATE, CHEM., vol. 19, 2008, pages 327
NUCLEIC ACIDS RES., vol. 22, pages 5076
TETRAHEDRON LETT., vol. 38, 1995, pages 55959
BIOORG. MED. CHEM., vol. 11, pages 2453
MOLECULAR PHARMACEUTICS, vol. 6, 2009, pages 669
BIOCONJUGATE, CHEM., vol. 19, 2008, pages 714
J. MOL. EVOL., vol. 56, 2003, pages 607
J. AM. CHEM. SOC., vol. 127, 2005, pages 10144
J. AM. CHEM. SOC., vol. 1119, 1997, pages 12420
PNAS, vol. 107, 2010, pages 15329 - 15334
CHEMBIOCHEM, vol. 12, 2011, pages 125 - 131
See also references of EP 2821489A4
ABE, H. ET AL.: "Rapid DNA chemical ligation for amplification of RNA and DNA signal", BIOCONJUG. CHEM., vol. 19, 2008, pages 327 - 333, XP055164981
UDA, M. ET AL.: "Synthesis of dumbbell-shaped nanocircular RNAs for improvement of permeability and stability", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 89 SHUNKI NENKAI KOEN YOKOSHU II, 2009, pages 1521, XP008174518
UDA, M. ET AL.: "Development of modified dumbbell-shaped RNA with cell-penetrating function for RNA interference", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 90 SHUNKI NENKAI KOEN YOKOSHU III, 2010, pages 785, XP008174517
RYAN J TAFT; KEN C PANG; TIMOTHY R MERCER; MARCEL DINGER; JOHN S MATTICK, J PATHOL., vol. 220, 2010, pages 126 - 139
FIRE A; XU S; MONTGOMERY M; KOSTAS S; DRIVER S; MELLO C, NATURE, vol. 391, 1998, pages 806 - 11
SAYDA M. ELBASHIR; JAVIER MARTINEZ; AGNIESZKA PATKANIOWSKA; WINFRIED LENDECKEL; THOMAS TUSCHL, EMBO J., vol. 20, 2001, pages 6877 - 6888
JOHN C. BURNETT; JOHN J. ROSSI; KATRIN TIEMANN, BIOTECHNOL. J., vol. 6, 2011, pages 1130 - 1146
BIOCONJUGATE, CHEM., vol. 19, 2008, pages 327
NUCLEIC ACIDS RES., vol. 22, pages 5076
TETRAHEDRON LETT., vol. 38, 1995, pages 55959
BIOORG. MED. CHEM., vol. 11, pages 2453
MOLECULAR PHARMACEUTICS, vol. 6, 2009, pages 669
BIOCONJUGATE, CHEM., vol. 19, 2008, pages 714
J. MOL. EVOL., vol. 56, 2003, pages 607
J. AM. CHEM. SOC., vol. 127, 2005, pages 10144
J. AM. CHEM. SOC., vol. 1119, 1997, pages 12420
PNAS, vol. 107, 2010, pages 15329 - 15334
CHEMBIOCHEM, vol. 12, 2011, pages 125 - 131
See also references of EP 2821489A4
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
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