METHOD FOR CONTROLLING BIOOXIDATION REACTIONS

Title:

METHOD FOR CONTROLLING BIOOXIDATION REACTIONS

Document Type and Number:

WIPO Patent Application WO2004065644

Kind Code:

A3

Abstract:

Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate and carbon dioxide evolution rate from the reaction mixture; (3) determining the instantaneous rates of substrate and cosubstrate consumption by solving simultaneous equations relating carbon dioxide evolution rate and oxygen consumption rate to the substrate oxidation stoichiometry, the cosubstrate combustion stoichiometry, and optionally the biomass formation stoichiometry; (4) simultaneously adjusting the substrate and cosubstrate addition rates to the rates of substrate oxidation and cosubstrate consumption in order to maximize the rate of product formation while simultaneously minimizing the rate of cosubstrate usage. The method provides a rapid means of controlling fed-batch biooxidation reactions which can employ in-line techniques and is broadly applicable for diverse oxidation reactions.

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Inventors:

ANDERSON KEVIN W (US)
WENZEL J DOUGLAS (US)

Application Number:

PCT/US2004/000907

Publication Date:

April 28, 2005

Filing Date:

January 14, 2004

Export Citation:

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Assignee:

COGNIS CORP (US)
ANDERSON KEVIN W (US)
WENZEL J DOUGLAS (US)

International Classes:

C12P7/44; C12P7/46; C12P7/64; C22B; (IPC1-7): C12P7/44; C12P7/46; C12P7/64

Foreign References:

US5962285A

1999-10-05

Other References: