Title:
METHOD OF CONTROLLING CRYSTALLISATION
Document Type and Number:
WIPO Patent Application WO/2011/027097
Kind Code:
A3
Abstract:
The invention provides a method of crystallising a compound comprising either: (i) providing a first confined solution comprising the compound; and adding more of the compound to and/or increasing the degree of saturation of the first confined solution, whereby to provide a resultant second confined solution that comprises more compound and/or that has a greater degree of supersaturation relative to a confined supersaturated solution of the same compound stabilised solely by being confined; or (ii) providing a first confined melt comprising the compound; and cooling and/or increasing the pressure of the first confined melt, whereby to provide a resultant second confined melt that is cooler and/or is more pressurised relative to a confined supercooled melt of the same compound stabilised solely by being confined, whereby to effect the crystallising under confinement and under thermodynamic control.
Inventors:
COOPER SHARON JANE (GB)
NICHOLSON CATHERINE EMMA (GB)
NICHOLSON CATHERINE EMMA (GB)
Application Number:
PCT/GB2010/001611
Publication Date:
April 28, 2011
Filing Date:
August 26, 2010
Export Citation:
Assignee:
UNIV DURHAM (GB)
COOPER SHARON JANE (GB)
NICHOLSON CATHERINE EMMA (GB)
COOPER SHARON JANE (GB)
NICHOLSON CATHERINE EMMA (GB)
International Classes:
A61K9/14; B01D9/00
Domestic Patent References:
| WO2000054865A1 | 2000-09-21 | |||
| WO2005089375A2 | 2005-09-29 | |||
| WO2008155570A1 | 2008-12-24 |
Foreign References:
| US6383233B1 | 2002-05-07 |
Attorney, Agent or Firm:
NAISMITH, Robert Stewart et al. (Aurora120 Bothwell Street, Glasgow G2 7JS, GB)
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