METHOD OF CONTROLLING THE PROLIFERATION OF VASCULAR ENDOTHELIAL CELLS AND INHIBITING LUMEN FORMATION

Title:

METHOD OF CONTROLLING THE PROLIFERATION OF VASCULAR ENDOTHELIAL CELLS AND INHIBITING LUMEN FORMATION

Document Type and Number:

WIPO Patent Application WO/2005/115408

Kind Code:

A1

Abstract:

[PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. [MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

Inventors:

TOKUDA MASAAKI (JP)
TSUKAMOTO IKUKO (JP)
KONISHI RYOJI (JP)
KUBOTA YASUO (JP)
IZUMORI KEN (JP)

Application Number:

PCT/JP2005/009689

Publication Date:

December 08, 2005

Filing Date:

May 26, 2005

Export Citation:

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Assignee:

UNIV KAGAWA NAT UNIV CORP (JP)
TOKUDA MASAAKI (JP)
TSUKAMOTO IKUKO (JP)
KONISHI RYOJI (JP)
KUBOTA YASUO (JP)
IZUMORI KEN (JP)

International Classes:

A61K31/7004; A61P9/00; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07H3/02; C07H3/08; (IPC1-7): A61K31/7004; A23K1/16; A23L1/30; A61P19/02; A61P27/02; A61P35/00; A61P43/00; C07H3/02; C07H3/08

Domestic Patent References:

WO2003097820A1

2003-11-27

Other References: