Title:
METHOD FOR CREATING EQUATION FOR COMPUTING PROGNOSIS IN LUNG ADENOCARCINOMA USING IMMUNE FACTORS AS INDEXES, AND METHOD FOR PREDICTING PROGNOSIS THEREIN
Document Type and Number:
WIPO Patent Application WO/2016/181912
Kind Code:
A1
Abstract:
Provided are a method for more easily and quickly predicting the prognosis in lung adenocarcinoma, and a method for creating a computing equation for embodying the aforesaid method.
The method according to the present invention for creating an equation for computing prognosis is characterized by comprising: detecting the expression of PD-L1, Gal-9 and XAGE1 in specimens obtained from a plurality of lung adenocarcinoma patients using an immunostaining technique; on the basis of first data, said first data being obtained by binarizing a first score that is specified on the basis of the distribution range and expression intensity of PD-L1 of tumor in a tumor tissue, second data, said second data being obtained by binarizing a second score that is specified on the basis of the distribution range and expression intensity of Gal-9 of tumor in a tumor tissue, and third data, said third data being obtained by binarizing on the basis of the presence or absence of XAGE1 expression, dividing the lung adenocarcinoma patients into a good-prognosis cluster and a poor-prognosis cluster; and determining the computing equation for dividing the good-prognosis cluster and the poor-prognosis cluster by multivariate analysis using the first score, second score and third data as explanatory variables. The method according to the present invention for predicting the prognosis in lung adenocarcinoma is characterized by comprising substituting first and second scores and third data detected from a specimen of a subject into the computing equation determined above and predicting the prognosis of the subject by computation.
Inventors:
OHUE YOSHIHIRO (JP)
OKA MIKIO (JP)
KUROSE KOJI (JP)
NAKAYAMA EIICHI (JP)
OKA MIKIO (JP)
KUROSE KOJI (JP)
NAKAYAMA EIICHI (JP)
Application Number:
PCT/JP2016/063687
Publication Date:
November 17, 2016
Filing Date:
May 06, 2016
Export Citation:
Assignee:
KAWASAKI GAKUEN EDUCATIONAL FOUND (JP)
International Classes:
G01N33/574; G01N33/48; G01N33/53
Foreign References:
| JP2012515334A | 2012-07-05 | |||
| JP2014158500A | 2014-09-04 |
Other References:
YOSHIHIRO OUE: "Antibody, CD 4 and CD 8 T- cell response against XAGE-1b (GAGED2a) in non-small cell lung cancer patients", KAWASAKI MEDICAL JOURNAL, vol. 37, no. 4, 2011, pages 223 - 232
SCHULKENS I. A. ET AL.: "Galectin Expression Profiling Identifies Galectin-1 and Galectin- 9A5 as Prognostic Factors in Stage I/II Non- Small Cell Lung Cancer", PLOS ONE, vol. 9, no. 9, September 2014 (2014-09-01), pages 1 - 9, XP055329346
WAKI KAYOKO ET AL.: "PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer", CANCER SCI, vol. 10 5, no. 10, October 2014 (2014-10-01), pages 1229 - 1235, XP055329355
F. HOFFMANN-LA ROCHE: "U.S. FDA grants Breakthrough Therapy Designation for Roche's investigational cancer immunotherapy MPDL3280A (anti-PDL1) in non- small cell lung cancer", MEDIA RELEASE, pages 1 - 3, XP055329363, Retrieved from the Internet [retrieved on 20160629]
YOSHIHIRO OUE ET AL.: "Haisengan de Fukusu no Men'eki Bunshi o Shihyo to suru Haisengan Kanja no Yogo Yosokuho", KANSAI . TOKAI CHIKU IKEI DAIGAKU SHIN GIJUTSU SETSUMEIKAI, 29 October 2015 (2015-10-29), Retrieved from the Internet [retrieved on 20160629]
SCHULKENS I. A. ET AL.: "Galectin Expression Profiling Identifies Galectin-1 and Galectin- 9A5 as Prognostic Factors in Stage I/II Non- Small Cell Lung Cancer", PLOS ONE, vol. 9, no. 9, September 2014 (2014-09-01), pages 1 - 9, XP055329346
WAKI KAYOKO ET AL.: "PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer", CANCER SCI, vol. 10 5, no. 10, October 2014 (2014-10-01), pages 1229 - 1235, XP055329355
F. HOFFMANN-LA ROCHE: "U.S. FDA grants Breakthrough Therapy Designation for Roche's investigational cancer immunotherapy MPDL3280A (anti-PDL1) in non- small cell lung cancer", MEDIA RELEASE, pages 1 - 3, XP055329363, Retrieved from the Internet
YOSHIHIRO OUE ET AL.: "Haisengan de Fukusu no Men'eki Bunshi o Shihyo to suru Haisengan Kanja no Yogo Yosokuho", KANSAI . TOKAI CHIKU IKEI DAIGAKU SHIN GIJUTSU SETSUMEIKAI, 29 October 2015 (2015-10-29), Retrieved from the Internet
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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