Title:
METHOD FOR CREATING HISTOPATHOLOGICAL GROUND TRUTH MASKS USING SLIDE RESTAINING
Document Type and Number:
WIPO Patent Application WO/2019/139591
Kind Code:
A1
Abstract:
A method for generating a ground truth mask for a microscope slide having a tissue specimen placed thereon includes a step of staining the tissue specimen with hematoxylin and eosin (H&E) staining agents. A first magnified image of the H&E stained tissue specimen is obtained, e.g., with a whole slide scanner. The H&E staining agents are then washed from the tissue specimen. A second, different stain is applied to the tissue specimen, e.g., a special stain such as an IHC stain. A second magnified image of the tissue specimen stained with the second, different stain is obtained. The first and second magnified images are then registered to each other. An annotation (e.g., drawing operation) is then performed on either the first or the second magnified images so as to form a ground truth mask, the ground truth mask in the form of closed polygon region enclosing tumor cells present in either the first or second magnified image.
Inventors:
PENG LILY (US)
STUMPE MARTIN (US)
STUMPE MARTIN (US)
Application Number:
PCT/US2018/013353
Publication Date:
July 18, 2019
Filing Date:
January 11, 2018
Export Citation:
Assignee:
GOOGLE LLC (US)
International Classes:
G06K9/00
Foreign References:
| US20170160171A1 | 2017-06-08 | |||
| US201715621837A | 2017-06-13 | |||
| US20170019051W | 2017-02-23 | |||
| US201514839452A | 2015-08-28 | |||
| US201615395530A | 2016-12-30 |
Other References:
ANONYMOUS: "Histology - Wikipedia", 11 April 2017 (2017-04-11), XP055506212, Retrieved from the Internet [retrieved on 20180911]
C. SZEGEDY ET AL.: "Going Deeper with Convolutions", ARXIV:1409.4842 [CS.CV, September 2014 (2014-09-01)
C. SZEGEDY ET AL.: "Rethinking the inception Architecture for Computer Vision", ARXIV:1512.00567 [CS.CV, December 2015 (2015-12-01)
C. SZEGEDY ET AL.: "Inception-v4, Inception-ResNet and the impact of Residual Connections on Learning", ARXIV:1602.0761 [CS.CV, February 2016 (2016-02-01)
C. SZEGEDY ET AL.: "Going Deeper with Convolutions", ARXIV:1409.4842 [CS.CV, September 2014 (2014-09-01)
C. SZEGEDY ET AL.: "Rethinking the inception Architecture for Computer Vision", ARXIV:1512.00567 [CS.CV, December 2015 (2015-12-01)
C. SZEGEDY ET AL.: "Inception-v4, Inception-ResNet and the impact of Residual Connections on Learning", ARXIV:1602.0761 [CS.CV, February 2016 (2016-02-01)
Attorney, Agent or Firm:
FAIRHALL, Thomas, A. et al. (US)
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