METHOD OF CREATING REMOVABLE BARRIERS IN MICROFABRICATED FLUIDIC DEVICES

WIPO Patent Application WO/2010/016916

A3

A method for creating a removable barrier in a microfluidic apparatus is carried out by: (a) providing a microfluidic apparatus having at least a first chamber and a second chamber, each including at least an inlet, wherein the first and second chamber are separated from one another by a plurality of barrier elements, the plurality of barrier elements defining a barrier zone, (b) introducing a liquid sample into the apparatus through the inlet of the first or second chamber to create a retained continuous liquid phase in one chamber, a continuous gas phase in the other chamber, and a gas/liquid interface between the first and second chamber at the barrier zone, (c) releasing the interface from the barrier elements, and (d) advancing the liquid phase past the barrier zone into the gas chamber displacing the gas phase. In some embodiments the barrier elements are hydrophobic (for example, the barrier elements comprise a hydrophobic polymer. Devices such as chemotaxis devices incorporating such methods are also described.

ALLBRITTON NANCY (US)
SIMS CHRISTOPHER (US)
XU WEI (US)
BEAR JAMES (US)
UETRECHT ANDREA (US)

PCT/US2009/004510

May 14, 2010

August 06, 2009

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UNIV NORTH CAROLINA (US)
ALLBRITTON NANCY (US)
SIMS CHRISTOPHER (US)
XU WEI (US)
BEAR JAMES (US)
UETRECHT ANDREA (US)

G01N35/00; C12Q1/02; G01N37/00

WO2007096730A1

2007-08-30

US20060121600A1	2006-06-08
KR100445132B1	2004-08-21

MYERS BIGEL SIBLEY & SAJOVEC, P.A. (Raleigh, NC, US)

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