Title:
METHOD FOR CULTURE OF CORNEAL ENDOTHELIAL CELLS, PROCESS FOR PRODUCTION OF CORNEAL ENDOTHELIAL CELL SHEET FOR TRANSPLANTATION PURPOSES, AND CULTURE KIT FOR CORNEAL ENDOTHELIAL CELLS
Document Type and Number:
WIPO Patent Application WO/2011/096593
Kind Code:
A1
Abstract:
Disclosed are: a method for culturing corneal endothelial cells, which has a low risk of infection, and can culture the cells in a large quantity at low cost; a process for producing a corneal endothelial cell sheet for transplantation purposes; a culture kit for corneal endothelial cells; and others.
Specifically disclosed are: a method for culturing corneal endothelial cells, which is characterized by culturing corneal endothelial cells in a liquid culture medium containing an ascorpic acid derivative; and others.
Inventors:
SHIMA NOBUYUKI (JP)
KIMOTO MIWA (JP)
YAMAGUCHI MASAHIRO (JP)
YAMAGAMI SATORU (JP)
KIMOTO MIWA (JP)
YAMAGUCHI MASAHIRO (JP)
YAMAGAMI SATORU (JP)
Application Number:
PCT/JP2011/052966
Publication Date:
August 11, 2011
Filing Date:
February 04, 2011
Export Citation:
Assignee:
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION (JP)
SHIMA NOBUYUKI (JP)
KIMOTO MIWA (JP)
YAMAGUCHI MASAHIRO (JP)
YAMAGAMI SATORU (JP)
SHIMA NOBUYUKI (JP)
KIMOTO MIWA (JP)
YAMAGUCHI MASAHIRO (JP)
YAMAGAMI SATORU (JP)
International Classes:
C12N5/071; C12M3/00; C12N1/00; C12N5/07
Domestic Patent References:
| WO2007043255A1 | 2007-04-19 | |||
| WO2004024852A1 | 2004-03-25 |
Foreign References:
| JP2008099565A | 2008-05-01 | |||
| JP2004298447A | 2004-10-28 | |||
| JP2006204501A | 2006-08-10 | |||
| JP2004222836A | 2004-08-12 | |||
| JP2005348736A | 2005-12-22 |
Other References:
NORIKO KOIZUMI: "Cultivated Corneal Endothelial Cell Sheet Transplantation in a Primate Model", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 113, no. 11, 2009, pages 1050 - 1059, XP008164080
TANAKA, Y. ET AL.: "Age-Dependent Telomere- Shortening Is Repressed by Phosphorylated a- Tocopherol Together With Cellular Longevity and Intracellular Oxidative-Stress Reduction in Human Brain Microvascular Endotheliocytes", J CELL BIOCHEM, vol. 102, no. 3, 2007, pages 689 - 703, XP008164081
SAITOH, Y. ET AL.: "Cytoprotection of Vascular Endotheliocytes by Phosphorylated Ascorbate Through Suppression of Oxidative Stress That Is Generated Immediately After Post-Anoxic Reoxygenation or With Alkylhydroperoxides", J CELL BIOCHEM, vol. 93, no. 4, 2004, pages 653 - 663, XP008164098
KOIZUMI N ET AL.: "Cultivated Corneal Endothelial Cell Sheet Transplantation in a Primate Model.", INVEST OPHTHALMOL VIS SCI., vol. 48, no. 10, 2007, pages 4519 - 26, XP008164101
See also references of EP 2532738A4
ENGELMANN K; FRIEDL P., CORNEA., vol. 14, 1995, pages 62 - 70
ZHU C; JOYCE NC, INVEST OPHTHALMOL VIS SCI., vol. 45, 2004, pages 1743 - 51
MIYATA K; DRAKE J; OSAKABE Y; HOSOKAWA Y; HWANG D; SOYA K; OSHIKA T; AMANO S., CORNEA, vol. 20, 2001, pages 59 - 63
HITANI K. ET AL., MOL VIS., vol. 14, 2008, pages 1 - 9
MIMURA T. ET AL., NVEST OPHTHALMOL VIS SCI., vol. 45, 2004, pages 2992 - 7
MIYATA K; DRAKE J; OSAKABE Y; HOSOKAWA Y; HWANG D; SOYA K; OSHIKA T; AMANO S, CORNEA, vol. 20, 2001, pages 59 - 63
TANAKA, Y. ET AL.: "Age-Dependent Telomere- Shortening Is Repressed by Phosphorylated a- Tocopherol Together With Cellular Longevity and Intracellular Oxidative-Stress Reduction in Human Brain Microvascular Endotheliocytes", J CELL BIOCHEM, vol. 102, no. 3, 2007, pages 689 - 703, XP008164081
SAITOH, Y. ET AL.: "Cytoprotection of Vascular Endotheliocytes by Phosphorylated Ascorbate Through Suppression of Oxidative Stress That Is Generated Immediately After Post-Anoxic Reoxygenation or With Alkylhydroperoxides", J CELL BIOCHEM, vol. 93, no. 4, 2004, pages 653 - 663, XP008164098
KOIZUMI N ET AL.: "Cultivated Corneal Endothelial Cell Sheet Transplantation in a Primate Model.", INVEST OPHTHALMOL VIS SCI., vol. 48, no. 10, 2007, pages 4519 - 26, XP008164101
See also references of EP 2532738A4
ENGELMANN K; FRIEDL P., CORNEA., vol. 14, 1995, pages 62 - 70
ZHU C; JOYCE NC, INVEST OPHTHALMOL VIS SCI., vol. 45, 2004, pages 1743 - 51
MIYATA K; DRAKE J; OSAKABE Y; HOSOKAWA Y; HWANG D; SOYA K; OSHIKA T; AMANO S., CORNEA, vol. 20, 2001, pages 59 - 63
HITANI K. ET AL., MOL VIS., vol. 14, 2008, pages 1 - 9
MIMURA T. ET AL., NVEST OPHTHALMOL VIS SCI., vol. 45, 2004, pages 2992 - 7
MIYATA K; DRAKE J; OSAKABE Y; HOSOKAWA Y; HWANG D; SOYA K; OSHIKA T; AMANO S, CORNEA, vol. 20, 2001, pages 59 - 63
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF:
Claims: