Title:
METHOD FOR CULTURING 3-DIMENSIONAL LUNG CANCER ORGANOID AND METHOD FOR PREPARING PATIENT-DERIVED XENOGRAFT ANIMAL MODEL USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/035618
Kind Code:
A1
Abstract:
The present invention relates to a method for culturing a 3-dimensional lung cancer organoid and a method for preparing a patient-derived xenograft animal model using the same. More specifically, the present invention relates to a method for culturing a 3-dimensional lung cancer organoid, a lung cancer organoid prepared by the method, a medium composition for culturing the lung cancer organoid, a method for preparing a xenograft animal model using the lung cancer organoid, a patient-derived lung cancer organoid xenograft animal model prepared by the method, and a method for analyzing the therapeutic efficacy of an anticancer agent and a method for screening an anticancer agent using the animal model.
Inventors:
JANG SE JIN (KR)
KIM MIN SUH (KR)
SUH YOUNG AH (KR)
MUN HYE MIN (KR)
OH JU HEE (KR)
KIM MIN SUH (KR)
SUH YOUNG AH (KR)
MUN HYE MIN (KR)
OH JU HEE (KR)
Application Number:
PCT/KR2018/009254
Publication Date:
February 21, 2019
Filing Date:
August 13, 2018
Export Citation:
Assignee:
UNIV ULSAN FOUND IND COOP (KR)
ASAN FOUND (KR)
ASAN FOUND (KR)
International Classes:
C12N5/09; A01K67/027; G01N33/50
Domestic Patent References:
WO2016083613A2 | 2016-06-02 | |||
WO2016112172A1 | 2016-07-14 | |||
WO2016015158A1 | 2016-02-04 |
Foreign References:
KR20140133399A | 2014-11-19 | |||
KR101674468B1 | 2016-11-10 |
Other References:
"Current Protocols in Pharmacology", March 2013, JOHN WILEY & SONS, INC., Hoboken, NJ, USA, ISBN: 978-0-471-14175-4, article DEROSE, YOKO S.: "Patient-derived models of human breast cancer: Protocols for in vitro and in vivo applications in tumor biology and translational medicine", XP055576552, DOI: 10.1002/0471141755.ph1423s60
BARKAUSKAS, CHRISTINA E. ET AL.: "Lung organoids: current uses and future promise", DEVELOPMENT, vol. 144, no. 6, 15 March 2017 (2017-03-15), pages 986 - 997, XP055576557
See also references of EP 3670649A4
BARKAUSKAS, CHRISTINA E. ET AL.: "Lung organoids: current uses and future promise", DEVELOPMENT, vol. 144, no. 6, 15 March 2017 (2017-03-15), pages 986 - 997, XP055576557
See also references of EP 3670649A4
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF:
Previous Patent: DISPLAY APPARATUS AND METHOD FOR PROVIDING CONTENT THEREOF
Next Patent: METHOD FOR DISPLAYING CONTENT AND ELECTRONIC DEVICE THEREOF
Next Patent: METHOD FOR DISPLAYING CONTENT AND ELECTRONIC DEVICE THEREOF