Title:
METHOD FOR CULTURING HEMATOPOIETIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2021/132627
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a culturing method and a production method for hematopoietic stem cells which can be used for hematopoietic stem cell transplantation. The method for culturing hematopoietic stem cells according to the present invention comprises culturing a cell population including hematopoietic stem cells in a medium containing at least one compound represented by formula (1) or a salt thereof.
Inventors:
NAKANE ATSUSHI (JP)
NAGATA HIDETAKA (JP)
ASANO SHIGEHIRO (JP)
MIYANISHI MASANORI (JP)
SUDA HITOSHI (JP)
SHIODA YUSUKE (JP)
NAGATA HIDETAKA (JP)
ASANO SHIGEHIRO (JP)
MIYANISHI MASANORI (JP)
SUDA HITOSHI (JP)
SHIODA YUSUKE (JP)
Application Number:
PCT/JP2020/048917
Publication Date:
July 01, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
NEXTGEM INC (JP)
NEXTGEM INC (JP)
International Classes:
C12N5/0789; A61K35/28; A61P7/00; A61P43/00; C12N5/07
Domestic Patent References:
| WO2013110198A1 | 2013-08-01 |
Foreign References:
| JP2015504902A | 2015-02-16 | |||
| JPH04506669A | 1992-11-19 | |||
| US20170350879A1 | 2017-12-07 |
Other References:
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JAMES Y. CHEN ET AL.: "Hoxb5 marks long-term haematopoietic stem cells and reveals ahomogenous perivascular niche", NATURE, vol. 530, 2016, pages 223 - 227, XP055509455
FARES I ET AL., SCIENCE, vol. 345, 2014, pages 1509 - 1512
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ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, 2018, pages 8293 - 8296
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, no. 3, 2007, pages 336 - 340
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 14, 2010, pages 4112 - 4115
NATURE, vol. 25, no. 7655, 2017, pages 432 - 438
TETRAHEDRON LETT., vol. 39, 1998, pages 1533 - 1536
EUR. J. ORG. CHEM., 2003, pages 2098 - 2114
J. ORG. CHEM., vol. 69, 2004, pages 984 - 986
BIOORG. MED. CHEM. LETT., vol. 19, 2009, pages 382 - 385
BIOORG. CHEM., vol. 66, 2016, pages 63 - 71
"Angew. Chem. Int. Ed.", vol. 45, 2006, pages: 2082 - 2088
CHEM MED CHE, vol. 11, 2016, pages 1469 - 1479
CHEM MED CHEM, vol. 11, 2016, pages 1469 - 1479
AVERY, MITCHELL A. ET AL.: "Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 1. Synthesis and Comparative Molecular Field Analysis of C-9 Analogs of Artemisinin and 10-Deoxoartemisinin", J. MED. CHEM., vol. 36, 1993, pages 4264 - 4275, XP002126172
JAMES Y. CHEN ET AL.: "Hoxb5 marks long-term haematopoietic stem cells and reveals ahomogenous perivascular niche", NATURE, vol. 530, 2016, pages 223 - 227, XP055509455
FARES I ET AL., SCIENCE, vol. 345, 2014, pages 1509 - 1512
NOTTA F ET AL., SCIENCE, vol. 333, no. 6039, 8 July 2011 (2011-07-08), pages 218 - 21
SUGIMURA R. ET AL., NATURE, vol. 545, no. 7655, 25 May 2017 (2017-05-25), pages 432 - 438
TAYA Y. ET AL., SCIENCE, vol. 354, no. 6316, 2 December 2016 (2016-12-02), pages 1152 - 1155
"GenBank", Database accession no. NC _ 000077.6
"NOG mouse", BLOOD, vol. 100, no. 9, 2012, pages 1113 - 1124
UEDA T. ET AL., J. CLIN. INVEST., vol. 105, 2000, pages 1013 - 1021
JIGANG WANG ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 10111
YIN KWAN WONG ET AL., MED RES REV, vol. 37, 2017, pages 1492 - 1517
TETRAHEDRON LETTERS, vol. 43, 2002, pages 7235 - 7237
J. MED. CHEM., vol. 31, 1988, pages 645 - 650
CHEM COMMUN, vol. 50, 2014, pages 12652 - 12655
TETRAHEDRON, vol. 72, no. 32, 2016, pages 4931 - 4937
CHEMMEDCHEM, vol. 7, no. 12, 2012, pages 2204 - 2226
LETTERS, vol. 9, no. 21, 2007, pages 4107 - 4110
ACS CATALYSIS, vol. 7, no. 3, 2017, pages 1998 - 2001
J. ORG. CHEM., vol. 67, no. 4, 2002, pages 1253 - 1260
EUR. J. ORG. CHEM., 2002, pages 113 - 132
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", vol. 1, 1999, MARUZEN PUBLISHING CO., LTD.
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, 2018, pages 8293 - 8296
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, no. 3, 2007, pages 336 - 340
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 14, 2010, pages 4112 - 4115
NATURE, vol. 25, no. 7655, 2017, pages 432 - 438
TETRAHEDRON LETT., vol. 39, 1998, pages 1533 - 1536
EUR. J. ORG. CHEM., 2003, pages 2098 - 2114
J. ORG. CHEM., vol. 69, 2004, pages 984 - 986
BIOORG. MED. CHEM. LETT., vol. 19, 2009, pages 382 - 385
BIOORG. CHEM., vol. 66, 2016, pages 63 - 71
"Angew. Chem. Int. Ed.", vol. 45, 2006, pages: 2082 - 2088
CHEM MED CHE, vol. 11, 2016, pages 1469 - 1479
CHEM MED CHEM, vol. 11, 2016, pages 1469 - 1479
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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