Title:
METHOD FOR DESIGNATING DISEASE RELATING TO AMOUNT OF TDP-43 EXISTING IN CELLS
Document Type and Number:
WIPO Patent Application WO/2013/129603
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing and providing a method for designating a disease that relates to the amount of TDP-43 existing in cells and a method for producing a TDP-43 binding inhibitor. By collecting cells from a subject and measuring the existing amount of a test substance in the cells, the binding amount of the test substance to TDP-43 in the cells, etc., whether or not the subject suffers from a disease that relates to the amount of TDP-43 existing in cells is designated. By adding a medicine candidate, a medicine capable of significantly reducing the binding of the test substance to TDP-43 is produced.
Inventors:
TAKAHASHI NOBUHIRO (JP)
IZUMIKAWA KEIICHI (JP)
ISHIKAWA HIDEAKI (JP)
YOSHIKAWA HARUNORI (JP)
ISHOBE THOSHIAKI (JP)
TAOKA MASATO (JP)
NAKAYAMA HIROSHI (JP)
IZUMIKAWA KEIICHI (JP)
ISHIKAWA HIDEAKI (JP)
YOSHIKAWA HARUNORI (JP)
ISHOBE THOSHIAKI (JP)
TAOKA MASATO (JP)
NAKAYAMA HIROSHI (JP)
Application Number:
PCT/JP2013/055497
Publication Date:
September 06, 2013
Filing Date:
February 28, 2013
Export Citation:
Assignee:
UNIV TOKYO NAT UNIV CORP (JP)
UNIV TOKYO METROPOLITAN (JP)
UNIV TOKYO METROPOLITAN (JP)
International Classes:
C12Q1/68; A61K31/7088; A61P21/04; A61P25/16; A61P25/28; C40B30/06; G01N33/15; G01N33/50; G01N33/566; G01N33/68; C12N15/09
Domestic Patent References:
| WO2012162249A1 | 2012-11-29 |
Foreign References:
| JP4160497A | 1997-02-10 |
Other References:
MICHAEL J. STRONG ET AL.: "TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein.", MOL. CELL. NEUROSCI., vol. 35, 2007, pages 320 - 327, XP055162450
MICHAEL J. STRONG: "The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 288, 2010, pages 1 - 12, XP026793463
YA-FEI XU ET AL.: "Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, MotorDeficits, and Early Mortality in Transgenic Mice.", THE JOURNAL OF NEUROSCIENCE, vol. 30, 2010, pages 10851 - 10859, XP055162455
XIU SHAN ET AL.: "Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.", PNAS, vol. 107, 2010, pages 16325 - 16330, XP055162457
YUKO ARIIZUMI: "Reduced Expression of TDP-43 Changes the Structures of Subcellular Organelles", NIIGATA MEDICAL JOURNAL, vol. 125, 2011, pages 482 - 497, XP008174337
JEFFREY D. ROTHSTEIN ET AL.: "Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.", ANNALS OF NEUROLOGY, vol. 28, no. 1, 1990, pages 18 - 25, XP055163575
JINSHENG LU ET AL.: "Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin.", BRAIN RESEARCH BULLETIN, vol. 89, September 2012 (2012-09-01), pages 185 - 190, XP055162458
ROSEN D. R. ET AL., NATURE, vol. 362, no. 6415, 1993, pages 59 - 62
GREENWAY M. J. ET AL., NEUROLOGY, vol. 63, no. 10, 2004, pages 1936 - 1938
RATNAPARKHI A. ET AL., PLOS ONE, vol. 3, no. 6, 2008, pages E2334
ARAI T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 351, no. 3, 2006, pages 602 - 611
KWIATKOWSKI T. J. JR, SCIENCE, vol. 323, no. 5918, 2009, pages 1205 - 1208
MARUYAMA H. ET AL., NATURE, vol. 465, 2010, pages 223 - 226
ROTHSTEIN J. D. ET AL., ANN, NEUROL., vol. 28, 1990, pages 18 - 25
TROTTI D. ET AL., NAT. NEUROSCI., vol. 2, 1999, pages 427 - 433
ROTHSTEIN J. D., NEURON, vol. 16, 1996, pages 675 - 686
BRUIJN L. I. ET AL., NEURON, vol. 18, 1997, pages 327 - 338
HOWLAND D. S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 1604 - 1609
ROTHSTEIN, J. D., ANN. NEUROL., vol. 65, 2009, pages S3 - S9
LACOMBLEZ L., LANCET, vol. 347, 1996, pages 1425 - 1431
AKAIKE A. ET AL., EUR. J. PHARMACOL., vol. 241, 1993, pages 1 - 6
PFOHL-LESZKOWICZ A ET AL., BIOCHEMISTRY, vol. 30, 1991, pages 8045 - 8051
LAGIER-TOURENNE, C.; CLEVELAND, D. W., CELL, vol. 136, 2009, pages 1001 - 1004
ARAI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 351, 2006, pages 602 - 611
NEUMANN ET AL., SCIENCE, vol. 314, 2006, pages 130 - 133
CHEN-PLOTKIN ET AL., NAT. REV. NEUROL., vol. 6, 2010, pages 211 - 220
LAGIER-TOURENNE ET AL., HUM. MOL. GENET., vol. 19, 2010, pages R46 - R64
KABASHI ET AL., NAT. GENET., vol. 40, 2008, pages 572 - 574
SREEDHARAN ET AL., SCIENCE, vol. 319, 2008, pages 1668 - 1672
PESIRIDIS, G.S. ET AL., HUM. MOL. GENET., vol. 18, 2009, pages R156 - R162
ARAI T ET AL., BIOCHEM BIOPHYS RES COMMUN., vol. 351, 2006, pages 602 - 611
SEPHTON C.F. ET AL., J. BIOL. CHEM., vol. 286, 2011, pages 1204 - 1215
POLYMENIDOU M ET AL., NAT. NEUROSCI., vol. 14, no. 4, 2011, pages 459 - 68
TOLLERVEY J.R. ET AL., NAT. NEUROSCI., vol. 14, no. 4, 2011, pages 452 - 458
AYALA, Y.M. ET AL., EMBO J., vol. 30, no. 2, 2011, pages 277 - 288
SAMBROOK, J. ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
TOYOSAKA MORIIZUMI; TAKAMICHI NAKAMOTO: "Sensor Engineering", 1997, SHOKODO, CO., LTD.
TOSHIFUMI INADA; HARUHIKO SHIOMI: "Notebook for RNA Experiment", 1997, YODOSHA CO., LTD.
IIJIMA ET AL., THE PLANT JOURNAL, vol. 54, 2008, pages 949 - 962
HIRAI ET AL., PROC NATL ACAD SCI USA, vol. 101, no. 27, 2004, pages 10205 - 10210
SATO ET AL., THE PLANT JOURNAL, vol. 40, no. 1, 2004, pages 151 - 163
SHIMIZU ET AL., PROTEOMICS, vol. 5, 2005, pages 3919 - 3931
BASS B. L., CELL, vol. 101, 2000, pages 235 - 238
SHARP P. A., GENES DEV., vol. 15, 2001, pages 485 - 490
ZAMORE P. D., SCIENCE, vol. 296, 2002, pages 1265 - 1269
DERNBURG, A. F.; KARPEN, G. H., CELL, vol. 111, 2002, pages 159 - 162
JANASENA, CLIN. CHEM., vol. 45, 1999, pages 1628 - 1650
GORACZNIAK R. ET AL., NAT BIOTECHNOL., vol. 27, 2009, pages 257 - 263
SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
ARAI ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 351, 2006, pages 602 - 611
HAYANO ET AL., INTERACTION ANALYSIS. J. PROTEOME RES., vol. 7, 2008, pages 4183 - 4190
IZUMIKAWA ET AL., BIOCHEM J., vol. 413, no. 3, 2008, pages 505 - 516
TAOKA ET AL., ANAL. CHEM., vol. 82, no. 18, 2010, pages 7795 - 7803
NATSUME ET AL., ANAL. CHEM., vol. 74, 2002, pages 4725 - 4733
NAKAYAMA ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages E47
LING ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 2107, 2010, pages 13318 - 13323
KWIATKOWSKI ET AL., SCIENCE, vol. 323, 2009, pages 1205 - 1208
VANCE ET AL., SCIENCE, vol. 323, 2009, pages 1208 - 1211
ELDEN ET AL., NATURE, vol. 466, 2010, pages 1069 - 1075
FUJIYAMA-NAKAMURA ET AL., MOL CELL PROTEOMICS, vol. 8, 2009, pages 1552 - 1565
HAYANO ET AL., J. PROTEOME RES., vol. 7, pages 4183 - 4190
GELLERICH FN ET AL., PLOS ONE., vol. 4, no. 12, 2009, pages E8181
JAENISCH; DALEY, NAT MED., vol. 16, no. 8, 2010, pages 903 - 908
SEIGEL GM ET AL., MOL VIS., vol. 13, 8 June 2007 (2007-06-08), pages 823 - 832
PARDO ET AL., J. CEREB. BLOOD FLOW METAB., vol. 31, no. 1, 2011, pages 90 - 101
HERTZ L., J. CEREB. BLOOD FLOW METAB., vol. 31, no. 1, 2011, pages 384 - 387
MIURA D ET AL., CLINICAL & EXPERIMENTAL METASTASIS, vol. 21, 2004, pages 445 - 451
See also references of EP 2821504A4
MICHAEL J. STRONG: "The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS).", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 288, 2010, pages 1 - 12, XP026793463
YA-FEI XU ET AL.: "Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, MotorDeficits, and Early Mortality in Transgenic Mice.", THE JOURNAL OF NEUROSCIENCE, vol. 30, 2010, pages 10851 - 10859, XP055162455
XIU SHAN ET AL.: "Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.", PNAS, vol. 107, 2010, pages 16325 - 16330, XP055162457
YUKO ARIIZUMI: "Reduced Expression of TDP-43 Changes the Structures of Subcellular Organelles", NIIGATA MEDICAL JOURNAL, vol. 125, 2011, pages 482 - 497, XP008174337
JEFFREY D. ROTHSTEIN ET AL.: "Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.", ANNALS OF NEUROLOGY, vol. 28, no. 1, 1990, pages 18 - 25, XP055163575
JINSHENG LU ET AL.: "Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin.", BRAIN RESEARCH BULLETIN, vol. 89, September 2012 (2012-09-01), pages 185 - 190, XP055162458
ROSEN D. R. ET AL., NATURE, vol. 362, no. 6415, 1993, pages 59 - 62
GREENWAY M. J. ET AL., NEUROLOGY, vol. 63, no. 10, 2004, pages 1936 - 1938
RATNAPARKHI A. ET AL., PLOS ONE, vol. 3, no. 6, 2008, pages E2334
ARAI T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 351, no. 3, 2006, pages 602 - 611
KWIATKOWSKI T. J. JR, SCIENCE, vol. 323, no. 5918, 2009, pages 1205 - 1208
MARUYAMA H. ET AL., NATURE, vol. 465, 2010, pages 223 - 226
ROTHSTEIN J. D. ET AL., ANN, NEUROL., vol. 28, 1990, pages 18 - 25
TROTTI D. ET AL., NAT. NEUROSCI., vol. 2, 1999, pages 427 - 433
ROTHSTEIN J. D., NEURON, vol. 16, 1996, pages 675 - 686
BRUIJN L. I. ET AL., NEURON, vol. 18, 1997, pages 327 - 338
HOWLAND D. S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 1604 - 1609
ROTHSTEIN, J. D., ANN. NEUROL., vol. 65, 2009, pages S3 - S9
LACOMBLEZ L., LANCET, vol. 347, 1996, pages 1425 - 1431
AKAIKE A. ET AL., EUR. J. PHARMACOL., vol. 241, 1993, pages 1 - 6
PFOHL-LESZKOWICZ A ET AL., BIOCHEMISTRY, vol. 30, 1991, pages 8045 - 8051
LAGIER-TOURENNE, C.; CLEVELAND, D. W., CELL, vol. 136, 2009, pages 1001 - 1004
ARAI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 351, 2006, pages 602 - 611
NEUMANN ET AL., SCIENCE, vol. 314, 2006, pages 130 - 133
CHEN-PLOTKIN ET AL., NAT. REV. NEUROL., vol. 6, 2010, pages 211 - 220
LAGIER-TOURENNE ET AL., HUM. MOL. GENET., vol. 19, 2010, pages R46 - R64
KABASHI ET AL., NAT. GENET., vol. 40, 2008, pages 572 - 574
SREEDHARAN ET AL., SCIENCE, vol. 319, 2008, pages 1668 - 1672
PESIRIDIS, G.S. ET AL., HUM. MOL. GENET., vol. 18, 2009, pages R156 - R162
ARAI T ET AL., BIOCHEM BIOPHYS RES COMMUN., vol. 351, 2006, pages 602 - 611
SEPHTON C.F. ET AL., J. BIOL. CHEM., vol. 286, 2011, pages 1204 - 1215
POLYMENIDOU M ET AL., NAT. NEUROSCI., vol. 14, no. 4, 2011, pages 459 - 68
TOLLERVEY J.R. ET AL., NAT. NEUROSCI., vol. 14, no. 4, 2011, pages 452 - 458
AYALA, Y.M. ET AL., EMBO J., vol. 30, no. 2, 2011, pages 277 - 288
SAMBROOK, J. ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
TOYOSAKA MORIIZUMI; TAKAMICHI NAKAMOTO: "Sensor Engineering", 1997, SHOKODO, CO., LTD.
TOSHIFUMI INADA; HARUHIKO SHIOMI: "Notebook for RNA Experiment", 1997, YODOSHA CO., LTD.
IIJIMA ET AL., THE PLANT JOURNAL, vol. 54, 2008, pages 949 - 962
HIRAI ET AL., PROC NATL ACAD SCI USA, vol. 101, no. 27, 2004, pages 10205 - 10210
SATO ET AL., THE PLANT JOURNAL, vol. 40, no. 1, 2004, pages 151 - 163
SHIMIZU ET AL., PROTEOMICS, vol. 5, 2005, pages 3919 - 3931
BASS B. L., CELL, vol. 101, 2000, pages 235 - 238
SHARP P. A., GENES DEV., vol. 15, 2001, pages 485 - 490
ZAMORE P. D., SCIENCE, vol. 296, 2002, pages 1265 - 1269
DERNBURG, A. F.; KARPEN, G. H., CELL, vol. 111, 2002, pages 159 - 162
JANASENA, CLIN. CHEM., vol. 45, 1999, pages 1628 - 1650
GORACZNIAK R. ET AL., NAT BIOTECHNOL., vol. 27, 2009, pages 257 - 263
SAMBROOK, J.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
ARAI ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 351, 2006, pages 602 - 611
HAYANO ET AL., INTERACTION ANALYSIS. J. PROTEOME RES., vol. 7, 2008, pages 4183 - 4190
IZUMIKAWA ET AL., BIOCHEM J., vol. 413, no. 3, 2008, pages 505 - 516
TAOKA ET AL., ANAL. CHEM., vol. 82, no. 18, 2010, pages 7795 - 7803
NATSUME ET AL., ANAL. CHEM., vol. 74, 2002, pages 4725 - 4733
NAKAYAMA ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages E47
LING ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 2107, 2010, pages 13318 - 13323
KWIATKOWSKI ET AL., SCIENCE, vol. 323, 2009, pages 1205 - 1208
VANCE ET AL., SCIENCE, vol. 323, 2009, pages 1208 - 1211
ELDEN ET AL., NATURE, vol. 466, 2010, pages 1069 - 1075
FUJIYAMA-NAKAMURA ET AL., MOL CELL PROTEOMICS, vol. 8, 2009, pages 1552 - 1565
HAYANO ET AL., J. PROTEOME RES., vol. 7, pages 4183 - 4190
GELLERICH FN ET AL., PLOS ONE., vol. 4, no. 12, 2009, pages E8181
JAENISCH; DALEY, NAT MED., vol. 16, no. 8, 2010, pages 903 - 908
SEIGEL GM ET AL., MOL VIS., vol. 13, 8 June 2007 (2007-06-08), pages 823 - 832
PARDO ET AL., J. CEREB. BLOOD FLOW METAB., vol. 31, no. 1, 2011, pages 90 - 101
HERTZ L., J. CEREB. BLOOD FLOW METAB., vol. 31, no. 1, 2011, pages 384 - 387
MIURA D ET AL., CLINICAL & EXPERIMENTAL METASTASIS, vol. 21, 2004, pages 445 - 451
See also references of EP 2821504A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
Download PDF:
Claims:
Previous Patent: CELL BALANCING DEVICE
Next Patent: PROCESS FOR MANUFACTURING REDUCED IRON AGGLOMERATES
Next Patent: PROCESS FOR MANUFACTURING REDUCED IRON AGGLOMERATES