Title:
METHOD FOR DETECTING ATOPIC DERMATITIS
Document Type and Number:
WIPO Patent Application WO/2021/221138
Kind Code:
A1
Abstract:
Provided are a marker for detecting atopic dermatitis and a method for detecting atopic dermatitis employing said marker. The present invention provides a method for detecting atopic dermatitis in a subject, the method including a step for measuring the expression level of a gene or an expression product thereof in a biological sample collected from the subject.
Inventors:
FUKAGAWA SATOKO (JP)
SHIMA KYOKO (JP)
TAKADA NAOTO (JP)
INOUE TAKAYOSHI (JP)
ISHIKAWA JUNKO (JP)
KUWANO TETSUYA (JP)
SHIMA KYOKO (JP)
TAKADA NAOTO (JP)
INOUE TAKAYOSHI (JP)
ISHIKAWA JUNKO (JP)
KUWANO TETSUYA (JP)
Application Number:
PCT/JP2021/017112
Publication Date:
November 04, 2021
Filing Date:
April 28, 2021
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C12Q1/6809; C12N15/12; C12Q1/6813; G01N33/50; G01N33/53
Domestic Patent References:
| WO2018161062A1 | 2018-09-07 | |||
| WO2018008319A1 | 2018-01-11 | |||
| WO2014144289A2 | 2014-09-18 |
Foreign References:
| JP2005110602A | 2005-04-28 | |||
| JP2018000206A | 2018-01-11 | |||
| JP2017227619A | 2017-12-28 | |||
| JP2020074769A | 2020-05-21 | |||
| JP2019030272A | 2019-02-28 | |||
| JP2020074769A | 2020-05-21 |
Other References:
HIROSHI KAWASAKI, ET.AL.: "Reverse translational research on atopic dermatitis", EXPERIMENTAL MEDICINE, vol. 35, no. 1, 2017, JP , pages 33 - 39, XP009536991, ISSN: 0288-5514
GHOSH DEBAJYOTI, BERNSTEIN JONATHAN A., KHURANA HERSHEY GURJIT K., ROTHENBERG MARC E., MERSHA TESFAYE B.: "Leveraging Multilayered “Omics” Data for Atopic Dermatitis: A Road Map to Precision Medicine", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 9, 12 December 2018 (2018-12-12), Lausanne, CH , pages 2727, XP055869991, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02727
IZUHARA KENJI, YUKIE YAMAGUCHI, SHOICHIRO OHTA, SATOSHI NUNOMURA, YASUHIRO NANRI, YOSHINORI AZUMA, NORIKO NOMURA, YASUHIKO NOGUCHI: "Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, 6 April 2018 (2018-04-06), pages 1102, XP055869987, DOI: 10.3390/ijms 19041102
TAKEUCHI, S. ET AL.: "Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 95, 2019, pages 70 - 75, XP085809546, DOI: 10.1016/j.jdermsci.2019.07.005
NAGAO MIZUHO, INAGAKI SHINICHIRO, KAWANO TOSHIKI, AZUMA YOSHINORI, NOMURA NORIKO, NOGUCHI YASUHIKO, OHTA SHOICHIRO, KAWAGUCHI ATSU: "SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 141, no. 5, 1 May 2018 (2018-05-01), AMSTERDAM, NL , pages 1934 - 1936.e11, XP055869978, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.01.021
SMITH, A. M. ET AL.: "Standard machine learning approaches outperform deep representation learning on phenotype prediction from transcriptomics data", BMC BIOINFORMATICS, vol. 21, no. 119, 20 March 2020 (2020-03-20), pages 1 - 18, XP021274476, Retrieved from the Internet DOI: 10.1186/s12859-020-3427-8
GHOSH DEBAJYOTI, GHOSH DEBAJYOTI, DING LILI, SIVAPRASAD UMASUNDARI, GEH ESMOND, BIAGINI MYERS JOCELYN, BERNSTEIN JONATHAN, KHURANA: "Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 12, 30 December 2015 (2015-12-30), pages e0144316, XP055869976, DOI: 10.1371/journal.pone.0144316
INOUE, TAKAYOSHI ET AL.: "Comprehensive expression analysis of mRNA in sebum", THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 129, no. 5, pages 1170
ANONYMOUS: " Confirmation of changes in sebum RNA molecules in atopic dermatitis in infants", KAO GROUP - NEWS RELEASE, 16 October 2020 (2020-10-16), XP055869973, Retrieved from the Internet [retrieved on 20210701]
ALLERGY, vol. 57, 2002, pages 180 - 181
ANN CLIN BIOCHEM., vol. 49, 2012, pages 277 - 84
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 128, no. 12, 2018, pages 2431 - 2502
JPN. J. PEDIATR. ALLERGY CLIN. IMMUNOL, vol. 19, no. 5, 2005, pages 744 - 757
ALLERGOLOGY INTERNATIONAL, vol. 52, 2003, pages 123 - 130
J ALLERGY CLIN IMMUNOL, vol. 141, no. 5, 2018, pages 1934 - 1936
ALLERGOLOGY INTERNATIONAL, vol. 67, 2018, pages 124 - 130
J ALLERGY CLIN IMMUNOL, no. 20, 2020, pages 0091 - 6749
SKIN RES TECHNOL, vol. 7, no. 4, 2001, pages 227 - 37
SKIN RES TECHNOL, vol. 8, no. 3, 2002, pages 187 - 93
MED DEVICES (AUCKL, vol. 9, 2016, pages 409 - 417
MED DEVICES (AUCKL, vol. 11, 2018, pages 87 - 94
J TISSUE VIABILITY, vol. 28, no. 1, 2019, pages 1 - 6
J DIABETES RES
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 141, no. 6, 2018, pages 2094 - 2106
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 111, 2001, pages 2023 - 2033
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 108, 1998, pages 1491 - 1496
DERMATOLOGY, vol. 186, 1993, pages 23 - 31
EXP DERMATOL, vol. 10, 2001, pages 11 - 18
BR J DERMATOL, vol. 177, 2017, pages 1316 - 1321
LOVE MI ET AL., GENOME BIOL., 2014
BREIMAN L., MACHINE LEARNING, vol. 45, 2001, pages 5 - 32
KURSA ET AL., FUNDAMENTAL INFORMATICAE, vol. 101, 2010, pages 271 - 286
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 100, 2003, pages 12271 - 12276
BIOL. REPROD., vol. 58, 1998, pages 302 - 311
GRIFFITHS, A.D.DUNCAN, A.R., CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, February 1998 (1998-02-01), pages 102 - 108
CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, 1998, pages 102 - 108
"The UK Working Party", BR J DERMATOL, vol. 131, 1994, pages 406 - 416
GHOSH DEBAJYOTI, BERNSTEIN JONATHAN A., KHURANA HERSHEY GURJIT K., ROTHENBERG MARC E., MERSHA TESFAYE B.: "Leveraging Multilayered “Omics” Data for Atopic Dermatitis: A Road Map to Precision Medicine", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 9, 12 December 2018 (2018-12-12), Lausanne, CH , pages 2727, XP055869991, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02727
IZUHARA KENJI, YUKIE YAMAGUCHI, SHOICHIRO OHTA, SATOSHI NUNOMURA, YASUHIRO NANRI, YOSHINORI AZUMA, NORIKO NOMURA, YASUHIKO NOGUCHI: "Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, 6 April 2018 (2018-04-06), pages 1102, XP055869987, DOI: 10.3390/ijms 19041102
TAKEUCHI, S. ET AL.: "Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 95, 2019, pages 70 - 75, XP085809546, DOI: 10.1016/j.jdermsci.2019.07.005
NAGAO MIZUHO, INAGAKI SHINICHIRO, KAWANO TOSHIKI, AZUMA YOSHINORI, NOMURA NORIKO, NOGUCHI YASUHIKO, OHTA SHOICHIRO, KAWAGUCHI ATSU: "SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 141, no. 5, 1 May 2018 (2018-05-01), AMSTERDAM, NL , pages 1934 - 1936.e11, XP055869978, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.01.021
SMITH, A. M. ET AL.: "Standard machine learning approaches outperform deep representation learning on phenotype prediction from transcriptomics data", BMC BIOINFORMATICS, vol. 21, no. 119, 20 March 2020 (2020-03-20), pages 1 - 18, XP021274476, Retrieved from the Internet
GHOSH DEBAJYOTI, GHOSH DEBAJYOTI, DING LILI, SIVAPRASAD UMASUNDARI, GEH ESMOND, BIAGINI MYERS JOCELYN, BERNSTEIN JONATHAN, KHURANA: "Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 12, 30 December 2015 (2015-12-30), pages e0144316, XP055869976, DOI: 10.1371/journal.pone.0144316
INOUE, TAKAYOSHI ET AL.: "Comprehensive expression analysis of mRNA in sebum", THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 129, no. 5, pages 1170
ANONYMOUS: "
ALLERGY, vol. 57, 2002, pages 180 - 181
ANN CLIN BIOCHEM., vol. 49, 2012, pages 277 - 84
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 128, no. 12, 2018, pages 2431 - 2502
JPN. J. PEDIATR. ALLERGY CLIN. IMMUNOL, vol. 19, no. 5, 2005, pages 744 - 757
ALLERGOLOGY INTERNATIONAL, vol. 52, 2003, pages 123 - 130
J ALLERGY CLIN IMMUNOL, vol. 141, no. 5, 2018, pages 1934 - 1936
ALLERGOLOGY INTERNATIONAL, vol. 67, 2018, pages 124 - 130
J ALLERGY CLIN IMMUNOL, no. 20, 2020, pages 0091 - 6749
SKIN RES TECHNOL, vol. 7, no. 4, 2001, pages 227 - 37
SKIN RES TECHNOL, vol. 8, no. 3, 2002, pages 187 - 93
MED DEVICES (AUCKL, vol. 9, 2016, pages 409 - 417
MED DEVICES (AUCKL, vol. 11, 2018, pages 87 - 94
J TISSUE VIABILITY, vol. 28, no. 1, 2019, pages 1 - 6
J DIABETES RES
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 141, no. 6, 2018, pages 2094 - 2106
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 111, 2001, pages 2023 - 2033
THE JAPANESE JOURNAL OF DERMATOLOGY, vol. 108, 1998, pages 1491 - 1496
DERMATOLOGY, vol. 186, 1993, pages 23 - 31
EXP DERMATOL, vol. 10, 2001, pages 11 - 18
BR J DERMATOL, vol. 177, 2017, pages 1316 - 1321
LOVE MI ET AL., GENOME BIOL., 2014
BREIMAN L., MACHINE LEARNING, vol. 45, 2001, pages 5 - 32
KURSA ET AL., FUNDAMENTAL INFORMATICAE, vol. 101, 2010, pages 271 - 286
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 100, 2003, pages 12271 - 12276
BIOL. REPROD., vol. 58, 1998, pages 302 - 311
GRIFFITHS, A.D.DUNCAN, A.R., CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, February 1998 (1998-02-01), pages 102 - 108
CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, 1998, pages 102 - 108
"The UK Working Party", BR J DERMATOL, vol. 131, 1994, pages 406 - 416
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Download PDF:
Previous Patent: MEDICINE AND TEST KIT EACH USING ANTI-SARS-COV-2 ANTIBODY
Next Patent: SLEEP ANALYSIS DEVICE
Next Patent: SLEEP ANALYSIS DEVICE