Title:
METHOD FOR DETECTING BLADDER CANCER USING BLADDER CANCER-SPECIFIC EPIGENETIC MARKER GENE
Document Type and Number:
WIPO Patent Application WO/2014/168346
Kind Code:
A1
Abstract:
The present invention relates to a method for detecting methylation in the CpG island of bladder biomarker genes in order to provide information necessary in diagnosing bladder cancer or advanced stage bladder cancer; more specifically, it relates to a method for detecting a bladder cancer which is characterized in that promoter methylation of the bladder cancer-specific marker gene is confirmed in which the promoter part specifically undergoes methylation in bladder cancer transformed cells. According to the present invention, early diagnosis is possible as bladder cancer can be detected at an early transformation stage, and accurate and rapid diagnosis of bladder cancer is possible as compared to conventional methods.
Inventors:
AN SUNGWHAN (KR)
OH TAEJEONG (KR)
OH TAEJEONG (KR)
Application Number:
PCT/KR2014/002108
Publication Date:
October 16, 2014
Filing Date:
March 13, 2014
Export Citation:
Assignee:
GENOMICTREE INC (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/574
Domestic Patent References:
| WO2012116019A1 | 2012-08-30 |
Foreign References:
| KR20090056921A | 2009-06-03 | |||
| US20130041047A1 | 2013-02-14 | |||
| US20090175844A1 | 2009-07-09 | |||
| US20120230952A1 | 2012-09-13 |
Other References:
WOONBOK CHUNG ET AL.: "Biomarkers in Urine Sediments Detection of Bladder Cancer Using Novel DNA Methylation.", CANCER EPIDEMIOLOLOGY, BIOMARKERS AND PREVENTION., vol. 20, 2011, pages 1483 - 1491
RAJU KANDIMALLA ET AL.: "Genome-wide Analysis of CpG Island Methylation in Bladder Cancer Identified TBX2, TBX3, GATA2, and ZIC4 as pTa-Specific Prognostic Markers.", EUROPEAN UROLOGY, vol. 61, 2012, pages 1245 - 1256
SATISH KALARI ET AL.: "Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.", ADVANCES IN GENETICS., vol. 70, 2010, pages 277 - 308
RAJU KANDIMALLA ET AL.: "Genome-wide Analysis of CpG Island Methylation in Bladder Cancer Identified TBX2, TBX3, GATA2, and ZIC4 as pTa-Specific Prognostic Markers.", EUROPEAN UROLOGY, vol. 61, 2012, pages 1245 - 1256
SATISH KALARI ET AL.: "Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.", ADVANCES IN GENETICS., vol. 70, 2010, pages 277 - 308
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
이처영 (KR)
Download PDF: