METHOD OF DETECTING BRAIN TUMOR, BRAIN TUMOR-DETECTING AGENT TO BE USED THEREIN AND MEDICINAL COMPOSITION

Title:

METHOD OF DETECTING BRAIN TUMOR, BRAIN TUMOR-DETECTING AGENT TO BE USED THEREIN AND MEDICINAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2006/022114

Kind Code:

A1

Abstract:

It is intended to provide a method of detecting brain tumor whereby brain tumor can be surely detected at the early stage; a brain tumor-detecting agent to be used therein; and a medicinal composition for treating brain tumor. Detection of brain tumor based on the detection of an N-binding sugar chain A2G2F of a glycoprotein, which is specifically expressed in brain tumor, contributes to the early detection and treatment for brain tumor. Moreover, brain tumor can be surely detected at the early stage by using a lectin capable of binding specifically to the N-binding sugar chain A2G2F. A brain tumor-detecting agent having the lectin capable of binding specifically to the N-binding sugar chain A2G2F of the glycoprotein makes it possible to early an deasily detect brain tumor based on the sugar chain A2G2F. A medicinal composition containing as the active ingredient the lectin capable of binding specifically to the N-binding sugar chain A2G2F of the glycoprotein induces apoptosis in brain tumor cells and, therefore, is efficacious in preventing and treating diseases caused by brain tumor cells.

More Like This:

WO/2002/002738	HOST CELLS CONTAINING MULTIPLE INTEGRATING VECTORS
JP2021178825	COMBINATION THERAPY WITH ANTI-HER2 ANTIBODY-DRUG CONJUGATE AND BCL-2 INHIBITOR
JP7109008	Methods and compositions for detecting pancreatic cancer

Inventors:

YAMANAKA RYUYA (JP)
TSUCHIYA NAOTO (JP)
IKENAKA KAZUHIRO (JP)

Application Number:

PCT/JP2005/013955

Publication Date:

March 02, 2006

Filing Date:

July 29, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV NIIGATA (JP)
NAT INST NATURAL SCIENCES (JP)
YAMANAKA RYUYA (JP)
TSUCHIYA NAOTO (JP)
IKENAKA KAZUHIRO (JP)

International Classes:

C07K16/30; G01N33/574; (IPC1-7): G01N33/574; C07K16/30

Foreign References:

JP2004231555A

2004-08-19

Other References:

FUJIMOTO ET AL: "Systematic Analysis of N-Linked Sugar Chains from Whole Tissue Employing Partial Automation", ANALYTICAL BIOCHEMISTRY, vol. 267, no. 2, 15 February 1999 (1999-02-15), pages 336 - 343, XP002993791

Attorney, Agent or Firm:

Ushiki, Mamoru (Yusei Fukushi Kotohira Bldg. 14-1, Toranomon 1-chom, Minato-ku Tokyo 01, JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: METHOD OF QUANTIFYING L-PHENYLALANINE BY USING IMMOBILIZED ENZYME CHIP HAVING His-Tag-FUSED PHENYLAL...

Next Patent: WATER-REPELLENT/OIL-REPELLENT COMPOSITION