METHOD FOR DETECTING CANCER CELLS AND MONITORING CANCER THERAPY

WIPO Patent Application WO2005023180

A3

Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intraperitoneally, intrapancreatically, or in the lungs. These findings demonstrate the remarkable specificity of the Sindbis vector system that is relatively safe and can specifically target tumor cells throughout the body via the bloodstream.

JPH10502819	[Title of Invention] Oligonucleotide with anti-MDR-1 gene activity
WO/2000/055350	HUMAN CANCER ASSOCIATED GENE SEQUENCES AND POLYPEPTIDES
JP2003047484	SODIUM CHANNEL SPECIFIC TO PERIPHERAL NERVOUS SYSTEM, DNA ENCODING THE SAME, CRYSTALLIZATION, X-RAY DIFFRACTION, COMPUTER MOLECULAR MODELING, RATIONAL DRUG DESIGNING, DRUG SCREENING, AND METHODS FOR MANUFACTURING AND USING THE DRUG

MERUELO DANIEL (US)
TSENG JEN-CHIEH (US)

PCT/US2004/026671

June 16, 2005

August 17, 2004

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UNIV NEW YORK (US)
MERUELO DANIEL (US)
TSENG JEN-CHIEH (US)

A61K48/00; A61K49/00; A61K51/00; A61M36/14; C12N7/00; C12N15/63; C12Q1/70; A61K; (IPC1-7): C12N7/00; C12N15/63; A61K48/00

TSENG J.C. ET AL: "In Vivo Antitumor Activity of Sindbis Viral Vectors", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 94, no. 23, December 2002 (2002-12-01), pages 1790 - 1802, XP002904507

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