Title:
METHOD FOR DETECTING CORONAVIRUS USING ANGIOTENSIN-CONVERTING ENZYME II (ACE2)
Document Type and Number:
WIPO Patent Application WO/2021/227994
Kind Code:
A1
Abstract:
The present invention relates to a method for detection or quantitative analysis of a coronavirus particle and a spike protein (S protein) or any receptor-binding domain (RBD)-containing S protein fragment thereof by means of ligand-receptor interaction, i.e., a strong binding effect between an RBD of a coronavirus S protein and angiotensin-converting enzyme II (ACE2). As an alternative to an antibody necessary in a conventional immunoassay method, ACE2 can be used for coating a solid-phase surface to capture or enrich an analyte, and can also be coupled with a marker involved in signal generation. Depending on the properties and signal patterns of analytes, ACE2 can be used as an analyte recognizer independently or used in combination with antibodies.
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Inventors:
ZHOU MING (CN)
Application Number:
PCT/CN2021/092426
Publication Date:
November 18, 2021
Filing Date:
May 08, 2021
Export Citation:
Assignee:
ACCUCISE DIAGNOSTICS INC (CN)
SUZHOU ACCUCISE DIAGNOSTICS INC (CN)
SUZHOU ACCUCISE DIAGNOSTICS INC (CN)
International Classes:
G01N33/573; G01N33/569
Foreign References:
| US20050282154A1 | 2005-12-22 | |||
| US20030138894A1 | 2003-07-24 | |||
| CN107831317A | 2018-03-23 | |||
| CN1852921A | 2006-10-25 |
Other References:
XIUYUAN OU, LIU YAN, LEI XIAOBO, LI PEI, MI DAN, REN LILI, GUO LI, GUO RUIXUAN, CHEN TING, HU JIAXIN, XIANG ZICHUN, MU ZHIXIA, CHE: "Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV", NATURE COMMUNICATIONS, vol. 11, no. 1, XP055724997, DOI: 10.1038/s41467-020-15562-9
Attorney, Agent or Firm:
BEIJING LINGZHUAN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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