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Title:
METHOD OF DETECTING HUMAN SERUM ALBUMIN IN BIOLOGICAL FLUIDS
Document Type and Number:
WIPO Patent Application WO/2020/043087
Kind Code:
A1
Abstract:
A method for human serum albumin (HSA) detection in a biological fluid using small molecule, fluorescent compounds having aggregation-induced emission (AIE) characteristics includes contacting the biological fluid with a fluorescent compound to provide a mixture, irradiating the mixture with ultraviolet light, and determining a presence of human serum albumin when an observable emission is detected. The fluorescent compound binds with human serum albumin in the biological fluid and the binding of the compound with the human serum albumin produces the emission. The biological fluid can be urine. The compounds can be water soluble and can include tetrazole-tagged AIEgens. The present methods can be performed using conventional fluorescent spectrometers, normally present in hospitals, or using an HSA detection device. The HSA detection device is portable and can be used by a patient at home.

Inventors:
TANG BENZHONG (CN)
XIE SHENG (CN)
TU YUJIE (CN)
Application Number:
CN2019/102792
Publication Date:
March 05, 2020
Filing Date:
August 27, 2019
Export Citation:
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Assignee:
UNIV HONG KONG SCIENCE & TECHNOLOGY (CN)
International Classes:
G01N21/64; C07D257/04; C09K11/06
Domestic Patent References:
WO2019091389A12019-05-16
WO2015164784A12015-10-29
WO2018192521A12018-10-25
Foreign References:
CN102706839A2012-10-03
Other References:
TU Y. ET AL.: "Specific and Quantitative Detection of Albumin in Biological Fluids by Tetrazolate-Functionalized Water-Soluble AlEgens", ACSAPPL. MATER. INTERFACES, vol. 11, 25 July 2019 (2019-07-25), pages 29619 - 29629, XP055695503
YAN N. ET AL.: "Real-time monitoring of the dissolution kinetics of silver nanoparticles and nanowires in aquatic environments using an aggregation-induced emission fluorogen", CHEM. COMMUN., vol. 54, 9 April 2018 (2018-04-09), pages 4585 - 4588, XP055607896, DOI: 10.1039/C8CC02245C
XIE S. ET AL.: "Fluorogenic Ag+-Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining.", ANGEW. CHEM. INT. ED., vol. 57, 14 April 2018 (2018-04-14), pages 5750 - 5753, XP055607888, DOI: 10.1002/anie.201801653
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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