Title:
METHOD FOR DETECTING LUPUS ANTICOAGULANTS
Document Type and Number:
WIPO Patent Application WO/2012/173259
Kind Code:
A1
Abstract:
Provided is a simple method for detecting lupus anticoagulants without using blood plasma from healthy individuals, which is capable of distinguishing between blood-coagulation-factor deficiencies, even in blood samples originating from patients undergoing anticoagulant therapies using warfarin, heparin, or the like, without being affected by said anticoagulant therapies. The method for detecting lupus anticoagulants is characterized in that it involves the following three steps, (A), (B) and (C): (A) a step in which a buffering solution composition containing blood coagulation factors is added to a blood sample and to a diluted sample of said blood sample both before and during the measurement of the blood coagulation time; (B) a step in which the blood coagulation time is measured for each of the samples from step (A); and (C) a step in which the blood coagulation times of each of the samples obtained in step (B) are compared.
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Inventors:
IEKO MASAHIRO (JP)
MORIKAWA CHIZURU (JP)
MORIKAWA CHIZURU (JP)
Application Number:
PCT/JP2012/065433
Publication Date:
December 20, 2012
Filing Date:
June 15, 2012
Export Citation:
Assignee:
SCHOOL JURIDICAL PERSON HIGASHI NIPPON GAKUEN HEALTH SCIENCES UNIVERSITY OF HOKKAIDO (JP)
SEKISUI MEDICAL CO LTD (JP)
IEKO MASAHIRO (JP)
MORIKAWA CHIZURU (JP)
SEKISUI MEDICAL CO LTD (JP)
IEKO MASAHIRO (JP)
MORIKAWA CHIZURU (JP)
International Classes:
G01N33/86
Foreign References:
| JPH0650999B2 | 1994-07-06 |
Other References:
KAZUHIKO KAGAWA: "Blood coagulation compensation test", MODERN MEDICAL LABORATORY, vol. 34, no. 8, 1 August 2006 (2006-08-01), pages 735 - 742, XP008172319
MASAHIRO IEKO ET AL.: "Cross-Mixing Test to Detect Lupus Anticoagulant for Diagnosis of Antiphospholipid Syndrome", THE JAPANESE JOURNAL OF CLINICAL PATHOLOGY, vol. 57, no. 10, 25 October 2009 (2009-10-25), pages 990 - 998, XP008172335
NOBUKO KANNO ET AL.: "Lupus Anticoagulant Sokutei no Tameno Kessho Kentai Sakusei to Kensa no Genjo", MODERN MEDICAL LABORATORY, vol. 37, no. 13, 1 December 2009 (2009-12-01), pages 1484 - 1490, XP008172316
INTERNATIONAL CONSENSUS STATEMENT ON PRELIMINARY CLASSIFICATION CRITERIA FOR DEFINITE ANTIPHOSPHOLIPID SYNDROME, ARTHRITIS & RHEUMATISM, vol. 42, no. 7, July 1999 (1999-07-01), pages 1309 - 1311
KENSA TO GIJUTSU, vol. 34, no. 8, August 2006 (2006-08-01), pages 735 - 742
"Update of the guidelines for lupus anticoagulant detection", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 7, 2009, pages 1737 - 1740
MASAHIRO IEKO ET AL.: "Cross-Mixing Test to Detect Lupus Anticoagulant for Diagnosis of Antiphospholipid Syndrome", THE JAPANESE JOURNAL OF CLINICAL PATHOLOGY, vol. 57, no. 10, 25 October 2009 (2009-10-25), pages 990 - 998, XP008172335
NOBUKO KANNO ET AL.: "Lupus Anticoagulant Sokutei no Tameno Kessho Kentai Sakusei to Kensa no Genjo", MODERN MEDICAL LABORATORY, vol. 37, no. 13, 1 December 2009 (2009-12-01), pages 1484 - 1490, XP008172316
INTERNATIONAL CONSENSUS STATEMENT ON PRELIMINARY CLASSIFICATION CRITERIA FOR DEFINITE ANTIPHOSPHOLIPID SYNDROME, ARTHRITIS & RHEUMATISM, vol. 42, no. 7, July 1999 (1999-07-01), pages 1309 - 1311
KENSA TO GIJUTSU, vol. 34, no. 8, August 2006 (2006-08-01), pages 735 - 742
"Update of the guidelines for lupus anticoagulant detection", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 7, 2009, pages 1737 - 1740
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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