Title:
METHOD FOR DETECTING METHYLATION OF THE BOWEL-CANCER-SPECIFIC METHYLATION MARKER GPM6A GENE IN ORDER TO DIAGNOSE BOWEL CANCER
Document Type and Number:
WIPO Patent Application WO/2012/081928
Kind Code:
A2
Abstract:
The present invention relates to a method for detecting methylation of the bowel-cancer-specific methylation marker GPM6A (NM_201591, glycoprotein M6A) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The method for detecting methylation and a diagnostic composition, kit and nucleic-acid chip according to the present invention can be used to advantage in diagnosing bowel cancer more accurately and quickly than by normal methods as they permit bowel cancer to be diagnosed at the initial genetic transformation step and so allow early diagnosis.
Inventors:
AN SUNG WHAN (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
Application Number:
PCT/KR2011/009710
Publication Date:
June 21, 2012
Filing Date:
December 16, 2011
Export Citation:
Assignee:
GENOMICTREE INC (KR)
AN SUNG WHAN (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
AN SUNG WHAN (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
International Classes:
C12N15/12; C12Q1/68; G01N33/574
Foreign References:
| US5786146A | 1998-07-28 |
Other References:
KOPRESKI, M.S. ET AL., CLIN. CANCER RES., vol. 5, 1961
MIYASHIRO, I. ET AL., CLIN. CHEM., vol. 47, 2001, pages 505
CHEN, X.Q. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2297
ESTELLER, M. ET AL., CANCER RES., vol. 59, 1999, pages 67
SANCHEZ-CESPEDES, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
SOZZI, G. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2689
PALMISANO, W.A. ET AL., CANCER RES., vol. 60, 2000, pages 5954
SUEOKA, E. ET AL., CANCER RES., vol. 59, 1999, pages 1404
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219 - 27
GOESSL, C. ET AL., CANCER RES., vol. 60, 2000, pages 5941
ROBERTSON, K.D. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
SINGAL, R.; GINDER, G.D., BLOOD, vol. 93, 1999, pages 4059
ROBERTSON, K. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
MALIK, K.; BROWN, K.W., BRIT. J. CANCER, vol. 83, 2000, pages 1583
SANCHEZ-CESPEDEZ, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR
FRAGA ET AL., NUCLEIC ACID RES., vol. 31, 2003, pages 1765
See also references of EP 2653547A4
MIYASHIRO, I. ET AL., CLIN. CHEM., vol. 47, 2001, pages 505
CHEN, X.Q. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2297
ESTELLER, M. ET AL., CANCER RES., vol. 59, 1999, pages 67
SANCHEZ-CESPEDES, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
SOZZI, G. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2689
PALMISANO, W.A. ET AL., CANCER RES., vol. 60, 2000, pages 5954
SUEOKA, E. ET AL., CANCER RES., vol. 59, 1999, pages 1404
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219 - 27
GOESSL, C. ET AL., CANCER RES., vol. 60, 2000, pages 5941
ROBERTSON, K.D. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
SINGAL, R.; GINDER, G.D., BLOOD, vol. 93, 1999, pages 4059
ROBERTSON, K. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
MALIK, K.; BROWN, K.W., BRIT. J. CANCER, vol. 83, 2000, pages 1583
SANCHEZ-CESPEDEZ, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR
FRAGA ET AL., NUCLEIC ACID RES., vol. 31, 2003, pages 1765
See also references of EP 2653547A4
Attorney, Agent or Firm:
LEE, Cheo Young (KR)
이처영 (KR)
이처영 (KR)
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