Title:
METHOD FOR DETECTING THE METHYLATION OF COLON-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLON CANCER DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2011/055916
Kind Code:
A2
Abstract:
The present invention relates to a method for detecting the methylation of colon-cancer-specific methylation marker genes for colon cancer diagnosis, and more particularly, to a method which involves detecting the methylation of colon-cancer-specific methylation marker genes which are specifically methylated in colon cancer cells, and providing information for colon cancer diagnosis. Using the methylation detection method, and a composition, a kit and a nucleic acid chip for diagnosis according to the present invention, colon cancer can be diagnosed in an early transformation stage to enable the early diagnosis of colon cancer. The method of the present invention enables the diagnosis of colon cancer to be performed in a more accurate and quick manner as compared to conventional methods, and therefore can be effectively used.
Inventors:
AN SUNG WHAN (KR)
MOON YOUNG HO (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
MOON YOUNG HO (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
Application Number:
PCT/KR2010/007030
Publication Date:
May 12, 2011
Filing Date:
October 14, 2010
Export Citation:
Assignee:
GENOMICTREE INC (KR)
AN SUNG WHAN (KR)
MOON YOUNG HO (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
AN SUNG WHAN (KR)
MOON YOUNG HO (KR)
OH TAE JEONG (KR)
CHUNG HYUN CHEOL (KR)
International Classes:
C12Q1/68; C12N15/11
Foreign References:
| US5786146A | 1998-07-28 |
Other References:
KOPRESKI, M.S. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 1961
MIYASHIRO, I. ET AL., CLIN. CHEM., vol. 47, 2001, pages 505
CHEN, X.Q. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2297
ESTELLER, M. ET AL., CANCER RES., vol. 59, 1999, pages 67
SANCHEZ-CESPEDES, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
SOZZI, G. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2689
PALMISANO, W.A. ET AL., CANCER RES., vol. 60, 2000, pages 5954
SUEOKA, E. ET AL., CANCER RES., vol. 59, 1999, pages 1404
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219 - 27
GOESSL, C. ET AL., CANCER RES., vol. 60, 2000, pages 5941
ROBERTSON, K.D. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
CROSS, S. ET AL., CURR. OPIN. GENE DEVELOP., vol. 5, 1995, pages 309
SINGAL, R.; GINDER, G.D., BLOOD, vol. 93, 1999, pages 4059
ROBERTSON, K. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
MALIK, K.; BROWN, K.W., BRIT. J. CANCER, vol. 83, 2000, pages 1583
SANCHEZ-CESPEDEZ, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR
FRAGA ET AL., NUCLEIC ACID RES., vol. 31, 2003, pages 1765
See also references of EP 2497834A4
MIYASHIRO, I. ET AL., CLIN. CHEM., vol. 47, 2001, pages 505
CHEN, X.Q. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2297
ESTELLER, M. ET AL., CANCER RES., vol. 59, 1999, pages 67
SANCHEZ-CESPEDES, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
SOZZI, G. ET AL., CLIN. CANCER RES., vol. 5, 1999, pages 2689
PALMISANO, W.A. ET AL., CANCER RES., vol. 60, 2000, pages 5954
SUEOKA, E. ET AL., CANCER RES., vol. 59, 1999, pages 1404
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219 - 27
GOESSL, C. ET AL., CANCER RES., vol. 60, 2000, pages 5941
ROBERTSON, K.D. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
CROSS, S. ET AL., CURR. OPIN. GENE DEVELOP., vol. 5, 1995, pages 309
SINGAL, R.; GINDER, G.D., BLOOD, vol. 93, 1999, pages 4059
ROBERTSON, K. ET AL., CARCINOGENSIS, vol. 21, 2000, pages 461
MALIK, K.; BROWN, K.W., BRIT. J. CANCER, vol. 83, 2000, pages 1583
SANCHEZ-CESPEDEZ, M. ET AL., CANCER RES., vol. 60, 2000, pages 892
AHLQUIST, D.A. ET AL., GASTROENTEROL., vol. 119, 2000, pages 1219
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR
FRAGA ET AL., NUCLEIC ACID RES., vol. 31, 2003, pages 1765
See also references of EP 2497834A4
Attorney, Agent or Firm:
LEE, Cheo Young (KR)
이처영 (KR)
이처영 (KR)
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