Title:
METHOD FOR DETECTING NON-ALCOHOLIC FATTY LIVER DISEASE, KIT FOR DETECTING NON-ALCOHOLIC FATTY LIVER DISEASE, AND BIOMARKER FOR USE IN DETECTION OF NON-ALCOHOLIC FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/066162
Kind Code:
A1
Abstract:
A method for detecting non-alcoholic fatty liver disease comprises: obtaining a sample derived from a body fluid of a mammal; and detecting at least one molecule selected from the group consisting of 2-aminoadipic acid, 2-oxocaproic acid, 2-oxoglutaric acid, alanine, glutamic acid, tyrosine, lactic acid, uric acid, valine, pyruvic acid, phenylalanine and proline in the sample.
Inventors:
FUJIMOTO HIROTAKA (JP)
AOKI YUTAKA (JP)
SATO TAKA-AKI (JP)
KIMURA TAKESHI (JP)
MASUDA KATSUNORI (JP)
HEIKE YUJI (JP)
UYAMA SHIZUKA (JP)
SUZUKI KAZUHIKO (JP)
ASAMI MARIKO (JP)
URAYAMA KEVIN (JP)
HAYASHI KUNIYOSHI (JP)
AOKI YUTAKA (JP)
SATO TAKA-AKI (JP)
KIMURA TAKESHI (JP)
MASUDA KATSUNORI (JP)
HEIKE YUJI (JP)
UYAMA SHIZUKA (JP)
SUZUKI KAZUHIKO (JP)
ASAMI MARIKO (JP)
URAYAMA KEVIN (JP)
HAYASHI KUNIYOSHI (JP)
Application Number:
PCT/JP2019/024293
Publication Date:
April 02, 2020
Filing Date:
June 19, 2019
Export Citation:
Assignee:
SHIMADZU CORP (JP)
ST LUKES INTERNATIONAL UNIV (JP)
ST LUKES INTERNATIONAL UNIV (JP)
International Classes:
G01N33/53; G01N30/72; G01N30/88
Domestic Patent References:
| WO2013002381A1 | 2013-01-03 |
Foreign References:
| JP2018502286A | 2018-01-25 | |||
| JP2011503547A | 2011-01-27 | |||
| JP2016065873A | 2016-04-28 | |||
| JP2010500566A | 2010-01-07 |
Other References:
LAI, YI-SYUAN ET AL.: "Mass-spectrometry-based serum metabolomics of a C57BL/6J mouse model of high-fat-diet-induced non-alcoholic fatty liver disease development", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 63, no. 35, 9 September 2015 (2015-09-09), pages 7873 - 7884, XP055664718, DOI: 10.1021/acs.jafc.5b02830
Attorney, Agent or Firm:
NAGAI, Fuyuki et al. (JP)
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