Title:
METHOD FOR DETECTING NOVEL BRAF FUSION PRODUCT
Document Type and Number:
WIPO Patent Application WO/2012/096325
Kind Code:
A1
Abstract:
[Problem] To elucidate a polynucleotide which is a new cancer-causing gene, and to thereby provide a method for detecting the polynucleotide or a polypeptide encoded by the polynucleotide, and a kit and primer set for the method.
[Solution] The above-described detection method detects a fusion gene, which comprises a part of the CLN3 gene and a part of the BRAF gene, or a fusion protein encoded by the fusion gene. The above-described primer set and kit for detection each contains a sense primer which is designed from the part that encodes CLN3 and an antisense primer which is designed from the part that encodes BRAF.
Inventors:
SUZUKI ATSUSHI (JP)
ASAUMI MAKOTO (JP)
SHINDOU NOBUAKI (JP)
ASAUMI MAKOTO (JP)
SHINDOU NOBUAKI (JP)
Application Number:
PCT/JP2012/050422
Publication Date:
July 19, 2012
Filing Date:
January 12, 2012
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
SUZUKI ATSUSHI (JP)
ASAUMI MAKOTO (JP)
SHINDOU NOBUAKI (JP)
SUZUKI ATSUSHI (JP)
ASAUMI MAKOTO (JP)
SHINDOU NOBUAKI (JP)
International Classes:
C12Q1/68; C12N15/09
Other References:
DAVID T.W. JONES ET AL.: "Tandem Duplication Producing a Novel Oncogenic BRAF Fusion Gene Defines the Majority of Pilocytic Astrocytomas", CANCER RESEARCH, vol. 68, no. 21, November 2008 (2008-11-01), pages 8673 - 8677, XP008155753, DOI: doi:10.1158/0008-5472.CAN-08-2097
NALLASIVAM PALANISAMY ET AL.: "Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma", NATURE MEDICINE, vol. 16, no. 7, July 2010 (2010-07-01), pages 793 - 798, XP008155779, DOI: doi:10.1038/nm.2166
RAFFAELE CIAMPI ET AL.: "Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 1, January 2005 (2005-01-01), pages 94 - 101, XP002458858, DOI: doi:10.1172/JCI200523237
TERRY J. LERNER ET AL.: "Isolation of a Novel Gene Underlying Batten Disease", CLN3, CELL, vol. 82, September 1995 (1995-09-01), pages 949 - 957, XP002924096, DOI: doi:10.1016/0092-8674(95)90274-0
NALLASIVAM PALANISAMY ET AL.: "Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma", NATURE MEDICINE, vol. 16, no. 7, July 2010 (2010-07-01), pages 793 - 798, XP008155779, DOI: doi:10.1038/nm.2166
RAFFAELE CIAMPI ET AL.: "Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 1, January 2005 (2005-01-01), pages 94 - 101, XP002458858, DOI: doi:10.1172/JCI200523237
TERRY J. LERNER ET AL.: "Isolation of a Novel Gene Underlying Batten Disease", CLN3, CELL, vol. 82, September 1995 (1995-09-01), pages 949 - 957, XP002924096, DOI: doi:10.1016/0092-8674(95)90274-0
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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