Title:
METHOD FOR DETECTING NOVEL RET FUSED BODY
Document Type and Number:
WIPO Patent Application WO/2013/141266
Kind Code:
A1
Abstract:
[Problem] To clarify a polynucleotide that is a novel causative gene for cancer to thereby provide a method for detecting the aforesaid polynucleotide or a polypeptide encoded thereby and a kit and a primer set for the detection method.
[Solution] Based on a finding that a fused gene consisting of a part of PIBF1 gene and a part of RET gene, said fused gene occurring in some cancer patients, is a causative gene for cancer, a method for detecting a polynucleotide that is the aforesaid gene and a polypeptide encoded thereby has been constructed. According to this detection method, a fused gene consisting of a part of PIBF1 gene and a part of RET gene or a fused protein encoded thereby is detected. The aforesaid primer set or detection kit contains a sense primer that is designed on the basis of the part originating in PIBF1 gene and an antisense primer that is designed on the basis of the part originating in RET gene.
Inventors:
SUZUKI ATSUSHI (JP)
TSUNOYAMA KAZUHISA (JP)
ASAUMI MAKOTO (JP)
TSUNOYAMA KAZUHISA (JP)
ASAUMI MAKOTO (JP)
Application Number:
PCT/JP2013/057951
Publication Date:
September 26, 2013
Filing Date:
March 21, 2013
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C12Q1/68; C12N15/09; G01N33/50; G01N33/68
Domestic Patent References:
| WO2012014795A1 | 2012-02-02 |
Foreign References:
| JP2004514909A | 2004-05-20 |
Other References:
SANTORO, M. ET AL.: "RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 155, 2006, pages 645 - 653, XP055069996, DOI: doi:10.1530/eje.1.02289
MUSHOLT, P. B. ET AL.: "RET rearrangements in archival oxyphilic thyroid tumors: New insights in tumorigenesis and classification of Hurthle cell carcinomas?", SURGERY, vol. 134, 2003, pages 881 - 889
LIPSON, D. ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies", NATURE MEDICINE, vol. 18, no. 3, February 2012 (2012-02-01), pages 382 - 384, XP055239624, DOI: doi:10.1038/nm.2673
MUSHOLT, P. B. ET AL.: "RET rearrangements in archival oxyphilic thyroid tumors: New insights in tumorigenesis and classification of Hurthle cell carcinomas?", SURGERY, vol. 134, 2003, pages 881 - 889
LIPSON, D. ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies", NATURE MEDICINE, vol. 18, no. 3, February 2012 (2012-02-01), pages 382 - 384, XP055239624, DOI: doi:10.1038/nm.2673
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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