Title:
METHOD FOR DETECTING OCLN-ARHGAP26 GENE
Document Type and Number:
WIPO Patent Application WO/2017/033905
Kind Code:
A1
Abstract:
The present invention addresses the problem of elucidating a polynucleotide which is a novel causative gene for cancer, and providing, as a result, a method for detecting said polynucleotide or a polypeptide encoded thereby, a primer set therefor, and a detection kit. In the detection method, either a fusion gene comprising a portion of the OCLN gene and a portion of the ARHGAP26 gene, or a fusion protein encoded thereby is detected. The primer set includes: a sense primer designed from the portion encoding OCLN; and an antisense primer designed from the portion encoding ARHGAP26.
Inventors:
SASAKI HIROKI (JP)
ICHIKAWA HITOSHI (JP)
ASAUMI MAKOTO (JP)
TSUNOYAMA KAZUHISA (JP)
ICHIKAWA HITOSHI (JP)
ASAUMI MAKOTO (JP)
TSUNOYAMA KAZUHISA (JP)
Application Number:
PCT/JP2016/074440
Publication Date:
March 02, 2017
Filing Date:
August 23, 2016
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
NAT CANCER CT (JP)
NAT CANCER CT (JP)
International Classes:
C12N15/09; C12Q1/68
Domestic Patent References:
| WO2012139134A2 | 2012-10-11 | |||
| WO2015142293A1 | 2015-09-24 |
Other References:
YAO F ET AL.: "Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.", CELL REP., vol. 12, no. 2, July 2015 (2015-07-01), pages 272 - 285, XP055367218
CANCER GENOME ATLAS RESEARCH NETWORK: "Comprehensive molecular characterization of gastric adenocarcinoma.", NATURE, vol. 513, no. 7517, 2014, pages 202 - 209, XP055367224
PANAGOPOULOS I ET AL.: "MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23 q23).", GENES CHROMOSOMES CANCER, vol. 41, no. 4, 2004, pages 400 - 404, XP055367226
BORKHARDT A ET AL.: "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 16, 2000, pages 9168 - 9173, XP055367230
OSANAI M ET AL.: "Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes.", CANCER RES., vol. 66, no. 18, 2006, pages 9125 - 9133, XP055372589
CANCER GENOME ATLAS RESEARCH NETWORK: "Comprehensive molecular characterization of gastric adenocarcinoma.", NATURE, vol. 513, no. 7517, 2014, pages 202 - 209, XP055367224
PANAGOPOULOS I ET AL.: "MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23 q23).", GENES CHROMOSOMES CANCER, vol. 41, no. 4, 2004, pages 400 - 404, XP055367226
BORKHARDT A ET AL.: "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 16, 2000, pages 9168 - 9173, XP055367230
OSANAI M ET AL.: "Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes.", CANCER RES., vol. 66, no. 18, 2006, pages 9125 - 9133, XP055372589
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
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