Title:
METHOD FOR DETECTING PREDISPOSITION TO INFERTILITY OR PREGNANT STATE OF MAMMAL, METHOD FOR CONTROLLING PREGNANCY OR BIRTH AND METHOD FOR PREVENTING OR TREATING IMMUNE-MEDIATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2008/059798
Kind Code:
A1
Abstract:
It is intended to effectively detecting a predisposition to pregnancy or a pregnant state using a predetermined ratio of a cytokine produced by a T cell subset. The object can be achieved by a method for detecting a predisposition to infertility and/or a pregnant state of a mammal comprising a first step of measuring an amount of production of Th cytokine in the Golgi apparatus or rough endoplasmic reticulum in Th1, Th2 and Th3 CD4SP (single positive) cells of a mammal, and a second step of obtaining a BL ratio and a PL ratio and determining a predisposition to infertility (BL ratio) and a pregnant state (PL ratio) based on these ratios. BLratio: Th1/Th2 PL ratio: (Th2/Th3)/Th1
Inventors:
KUWABARA, Masato (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
桑原 正人 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
桑原 正人 (〒75 東京都千代田区九段南四丁目８番２４号 学校法人日本大学内 Tokyo, 1028275, JP)
Application Number:
JP2007/071933
Publication Date:
May 22, 2008
Filing Date:
November 12, 2007
Export Citation:
Assignee:
NIHON UNIVERSITY (8-24, Kudan-minami 4-chome Chiyoda-k, Tokyo 75, 1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 1028275, JP)
KUWABARA, Masato (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
学校法人日本大学 (〒75 東京都千代田区九段南四丁目８番２４号 Tokyo, 1028275, JP)
KUWABARA, Masato (8-24 Kudan-minami 4-chome,Chiyoda-k, Tokyo 75, 1028275, JP)
International Classes:
G01N33/53; A01K67/00; A23K1/10; A61K35/60; A61K38/21; G01N33/53; A01K67/00; A23K1/10; A61K35/56; A61K38/21
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (TMI ASSOCIATES 23rd Floor, Roppongi Hills Mori Tower 6-10-1, Roppongi, Minato-k, Tokyo 23, 1066123, JP)
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