Title:
METHOD FOR DETECTING REPLICATION OR COLONIZATION OF A BIOLOGICAL THERAPEUTIC
Document Type and Number:
WIPO Patent Application WO/2013/052915
Kind Code:
A3
Abstract:
Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid distinct from the administered therapy or locus thereof, thereby permitting assessment of the therapy and/or monitoring its progress.
Inventors:
SZALAY ALADAR A (US)
STRITZKER JOCHEN (DE)
HESS MICHAEL (DE)
STRITZKER JOCHEN (DE)
HESS MICHAEL (DE)
Application Number:
PCT/US2012/059126
Publication Date:
June 20, 2013
Filing Date:
October 05, 2012
Export Citation:
Assignee:
GENELUX CORP (US)
International Classes:
C12Q1/68; G01N33/50; G01N33/569; G01N33/574
Other References:
KAH-WHYE PENG ET AL: "Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides", NATURE MEDICINE, vol. 8, no. 5, 1 May 2002 (2002-05-01), pages 527 - 531, XP055049863, ISSN: 1078-8956, DOI: 10.1038/nm0502-527
KATHRIN M BERNT ET AL: "Enzyme-activated Prodrug Therapy Enhances Tumor-specific Replication of Adenovirus Vectors", CANCER RESEARCH, vol. 62, 1 November 2002 (2002-11-01), pages 6089 - 6098, XP055049866
A KANERVA ET AL: "Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus", GENE THERAPY, vol. 12, no. 1, 1 January 2005 (2005-01-01), pages 87 - 94, XP055049867, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302387
X GERARD ET AL: "Real-time monitoring of cell transplantation in mouse dystrophic muscles by a secreted alkaline phosphatase reporter gene", GENE THERAPY, vol. 16, no. 6, 1 June 2009 (2009-06-01), pages 815 - 819, XP055049870, ISSN: 0969-7128, DOI: 10.1038/gt.2009.28
NAGY J A ET AL: "SYSTEMIC DELIVERY OF A RECOMBINANT PROTEIN BY GENETICALLY MODIFIED MESOTHELIAL CELLS RESEEDED ON THE PARIETAL PERITONEAL SURFACE", GENE THERAPY,, vol. 2, no. 6, 1 January 1995 (1995-01-01), pages 402 - 410, XP001041792, ISSN: 0969-7128
SVENSJOE T ET AL: "CULTURED AUTOLOGOUS FIBROBLASTS AUGMENT EPIDERMAL REPAIR", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE US, vol. 73, no. 7, 15 April 2002 (2002-04-15), pages 1033 - 1041, XP001085427, ISSN: 0041-1337, DOI: 10.1097/00007890-200204150-00004
GHIVIZZANI S C ET AL: "DIRECT RETROVIRUS-MEDIATED GENE TRANSFER TO THE SYNOVIUM OF THE RABBIT KNEE: IMPLICATIONS FOR ARTHRITIS GENE THERAPY", GENE THERAPY,, vol. 4, no. 9, 1 September 1997 (1997-09-01), pages 977 - 982, XP001088432, ISSN: 0969-7128, DOI: 10.1038/SJ.GT.3300486
MAMOUN AHRAM ET AL: "A proteomic approach to characterize protein shedding", PROTEOMICS - CLINICAL APPLICATIONS, WILEY, DE, vol. 5, no. 1, 25 January 2005 (2005-01-25), pages 123 - 131, XP007911914, ISSN: 1862-8346, DOI: 10.1002/PMIC.200400912
KATHRIN M BERNT ET AL: "Enzyme-activated Prodrug Therapy Enhances Tumor-specific Replication of Adenovirus Vectors", CANCER RESEARCH, vol. 62, 1 November 2002 (2002-11-01), pages 6089 - 6098, XP055049866
A KANERVA ET AL: "Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus", GENE THERAPY, vol. 12, no. 1, 1 January 2005 (2005-01-01), pages 87 - 94, XP055049867, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302387
X GERARD ET AL: "Real-time monitoring of cell transplantation in mouse dystrophic muscles by a secreted alkaline phosphatase reporter gene", GENE THERAPY, vol. 16, no. 6, 1 June 2009 (2009-06-01), pages 815 - 819, XP055049870, ISSN: 0969-7128, DOI: 10.1038/gt.2009.28
NAGY J A ET AL: "SYSTEMIC DELIVERY OF A RECOMBINANT PROTEIN BY GENETICALLY MODIFIED MESOTHELIAL CELLS RESEEDED ON THE PARIETAL PERITONEAL SURFACE", GENE THERAPY,, vol. 2, no. 6, 1 January 1995 (1995-01-01), pages 402 - 410, XP001041792, ISSN: 0969-7128
SVENSJOE T ET AL: "CULTURED AUTOLOGOUS FIBROBLASTS AUGMENT EPIDERMAL REPAIR", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE US, vol. 73, no. 7, 15 April 2002 (2002-04-15), pages 1033 - 1041, XP001085427, ISSN: 0041-1337, DOI: 10.1097/00007890-200204150-00004
GHIVIZZANI S C ET AL: "DIRECT RETROVIRUS-MEDIATED GENE TRANSFER TO THE SYNOVIUM OF THE RABBIT KNEE: IMPLICATIONS FOR ARTHRITIS GENE THERAPY", GENE THERAPY,, vol. 4, no. 9, 1 September 1997 (1997-09-01), pages 977 - 982, XP001088432, ISSN: 0969-7128, DOI: 10.1038/SJ.GT.3300486
MAMOUN AHRAM ET AL: "A proteomic approach to characterize protein shedding", PROTEOMICS - CLINICAL APPLICATIONS, WILEY, DE, vol. 5, no. 1, 25 January 2005 (2005-01-25), pages 123 - 131, XP007911914, ISSN: 1862-8346, DOI: 10.1002/PMIC.200400912
Attorney, Agent or Firm:
SEIDMAN, Stephanie, L. et al. (4435 Eastgate MallSuite 40, San Diego CA, US)
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