Title:
METHOD OF DETECTING TAU PROTEIN AND TAU FRAGMENTS IN SERUM
Document Type and Number:
WIPO Patent Application WO/2011/109112
Kind Code:
A3
Abstract:
The present invention provides quantitative methods for the detection of tau protein and/or tau fragments. More specifically, the present invention provides quantitative methods for diagnosing a tauopathy or ruling out a tauopathy as the cause of disease, particularly the diagnosis and ruling of Alzheimer's disease. The present invention further provides a method for diagnosing a tauopathy by computing the ratio of two detected tau proteins or tau fragments.
Inventors:
DEBERNARDIS JOHN F (US)
ZINKOWSKI RAYMOND P (US)
ZINKOWSKI RAYMOND P (US)
Application Number:
PCT/US2011/000419
Publication Date:
October 27, 2011
Filing Date:
March 04, 2011
Export Citation:
Assignee:
EINSTEIN COLL MED (US)
DEBERNARDIS JOHN F (US)
ZINKOWSKI RAYMOND P (US)
DEBERNARDIS JOHN F (US)
ZINKOWSKI RAYMOND P (US)
International Classes:
A61K39/00; C07K16/00
Foreign References:
| US5492812A | 1996-02-20 | |||
| US20030194742A1 | 2003-10-16 | |||
| US20080050383A1 | 2008-02-28 |
Other References:
GOTZ ET AL.: "Tau Filament Formation in Transgenic Mice Expressing P301 L Tau.", J BIOL CHEM., vol. 276, no. 1, 2001, pages 529 - 34
WANG ET AL.: "Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model.", PROC NATL ACAD SCI USA, vol. 104, no. 24, 2007, pages 10252 - 7
BALLATORE ET AL.: "Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.", NAT REV NEUROSCI., vol. 8, no. 9, 2007, pages 663 - 72
DATABASE GENBANK [online] 21 February 2010 (2010-02-21), "microtubule-associated protein tau isoform 2 [Homo sapiens]", retrieved from http://www.pcbi.nlm.nih.gov/proteiN6754638?sat=138satkey=9254547 Database accession no. 005901.2
WANG ET AL.: "Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model.", PROC NATL ACAD SCI USA, vol. 104, no. 24, 2007, pages 10252 - 7
BALLATORE ET AL.: "Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.", NAT REV NEUROSCI., vol. 8, no. 9, 2007, pages 663 - 72
DATABASE GENBANK [online] 21 February 2010 (2010-02-21), "microtubule-associated protein tau isoform 2 [Homo sapiens]", retrieved from http://www.pcbi.nlm.nih.gov/proteiN6754638?sat=138satkey=9254547 Database accession no. 005901.2
Attorney, Agent or Firm:
ARNOLD, Craig, J. (Rothstein & Ebenstein LLP90 Park Avenu, New York NY, US)
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