Title:
METHOD FOR DETECTING VARIANT NUCLEIC ACIDS
Document Type and Number:
WIPO Patent Application WO/2023/115662
Kind Code:
A1
Abstract:
A method for detecting variant nucleic acids and the use thereof in the detection of samples. Specifically, the present invention relates to a method for detecting the presence and/or quantity of variant nucleic acids. The method comprises determining the presence and/or quantity of variant nucleic acids on the basis of a somatic mutation region and a background mutation region in a sample to be detected.
Inventors:
ZHANG ZHIHONG (CN)
ZHU PENGFEI (CN)
WU SHUAILAI (CN)
WANG CHENYANG (CN)
QIU FUJUN (CN)
HAN YUSHENG (CN)
ZHU PENGFEI (CN)
WU SHUAILAI (CN)
WANG CHENYANG (CN)
QIU FUJUN (CN)
HAN YUSHENG (CN)
Application Number:
PCT/CN2022/070974
Publication Date:
June 29, 2023
Filing Date:
January 10, 2022
Export Citation:
Assignee:
GUANGZHOU BURNING ROCK DX CO LTD (CN)
International Classes:
C12Q1/6886; C12N15/11; C12Q1/6869; G16B20/50; G16B30/10
Foreign References:
| CN112218957A | 2021-01-12 | |||
| CN112638152A | 2021-04-09 | |||
| CN111278993A | 2020-06-12 | |||
| CN110383385A | 2019-10-25 | |||
| CN113228190A | 2021-08-06 | |||
| CN107075730A | 2017-08-18 | |||
| CN112111565A | 2020-12-22 |
Other References:
WAN JONATHAN C. M., HEIDER KATRIN, GALE DAVINA, MURPHY SUZANNE, FISHER EYAL, MOULIERE FLORENT, RUIZ-VALDEPENAS ANDREA, SANTONJA AN: "ctDNA monitoring using patient-specific sequencing and integration of variant reads", SCIENCE TRANSLATIONAL MEDICINE, vol. 12, no. 548, 17 June 2020 (2020-06-17), pages eaaz8084, XP093073693, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaz8084
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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