Title:
METHOD FOR DETECTION OF CONDITION IN CONSCIOUSNESS DISORDER PATIENT AND KIT FOR THE DETECTION
Document Type and Number:
WIPO Patent Application WO/2007/094394
Kind Code:
A1
Abstract:
Disclosed is a method for detection of a condition in a consciousness disorder patient. The method comprises analyzing the amount and/or activity of a von Willebrand factor-cleaving enzyme in the patient. Also disclosed is a kit for detecting a condition in a consciousness disorder patient. The kit comprises an antibody capable of binding specifically to a von Willebrand factor-cleaving enzyme or a fragment of the antibody, or von Willebrand factor or a fragment thereof. Examples of the detection of cerebral vascular disorder, the detection of a condition include the detection of arteriosclerotic angiopathy or the detection or prediction of the degree of severity.
More Like This:
Inventors:
IGAMI KO (JP)
OKAZAKI TOMOHARU (JP)
SHINMYOZU KOICHI (JP)
ONO TOMOKO (JP)
FURUSAKI FUMIO (JP)
OKAZAKI TOMOHARU (JP)
SHINMYOZU KOICHI (JP)
ONO TOMOKO (JP)
FURUSAKI FUMIO (JP)
Application Number:
PCT/JP2007/052697
Publication Date:
August 23, 2007
Filing Date:
February 15, 2007
Export Citation:
Assignee:
MITSUBISHI KAGAKU IATRON INC (JP)
CHEMO SERO THERAPEUT RES INST (JP)
IGAMI KO (JP)
OKAZAKI TOMOHARU (JP)
SHINMYOZU KOICHI (JP)
ONO TOMOKO (JP)
FURUSAKI FUMIO (JP)
CHEMO SERO THERAPEUT RES INST (JP)
IGAMI KO (JP)
OKAZAKI TOMOHARU (JP)
SHINMYOZU KOICHI (JP)
ONO TOMOKO (JP)
FURUSAKI FUMIO (JP)
International Classes:
C12Q1/37; G01N33/573
Domestic Patent References:
| WO2005062054A1 | 2005-07-07 | |||
| WO2004029242A1 | 2004-04-08 | |||
| WO2004029242A1 | 2004-04-08 | |||
| WO2005062054A1 | 2005-07-07 | |||
| WO2006049300A1 | 2006-05-11 |
Other References:
"Kessensei Kesshoban Genshosei Shihanbyo (TTP)", JAPAN INTRACTABLE DISEASES INFORMATION, XP003016577, Retrieved from the Internet
FUJIKAWA K. ET AL.: "Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family", BLOOD, vol. 98, no. 6, 2001, pages 1662 - 1666, XP002972407
See also references of EP 1990421A4
K. FUJIKAWA ET AL., BLOOD, (U.S.A.), vol. 98, 2001, pages 1662 - 6
G. G. LEVY ET AL., NATURE, (UNITED KINGDOM), vol. 413, 2001, pages 488 - 494
M. FURLAN ET AL., BLOOD, (U.S.A.), vol. 87, 1996, pages 4223 - 4234 0
KOKAME K ET AL., THE BRITISH JOURNAL OF HAEMATOLOGY, (UNITED KINGDOM), vol. 129, 2005, pages 93 - 100
FUJIKAWA K. ET AL.: "Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family", BLOOD, vol. 98, no. 6, 2001, pages 1662 - 1666, XP002972407
See also references of EP 1990421A4
K. FUJIKAWA ET AL., BLOOD, (U.S.A.), vol. 98, 2001, pages 1662 - 6
G. G. LEVY ET AL., NATURE, (UNITED KINGDOM), vol. 413, 2001, pages 488 - 494
M. FURLAN ET AL., BLOOD, (U.S.A.), vol. 87, 1996, pages 4223 - 4234 0
KOKAME K ET AL., THE BRITISH JOURNAL OF HAEMATOLOGY, (UNITED KINGDOM), vol. 129, 2005, pages 93 - 100
Attorney, Agent or Firm:
MORITA, Kenichi (Itabashi-chuo Bldg. 67-8, Itabashi 2-chome, Itabashi-ku, Toky, 04 ., JP)
Download PDF: