Title:
METHOD FOR DETECTION OF DISEASE HAVING INSULIN-RESISTANT CONDITION
Document Type and Number:
WIPO Patent Application WO/2007/139224
Kind Code:
A1
Abstract:
Disclosed is a simple method for detecting a morbid condition of an insulin resistance disease, particularly type-2 diabetes. The method comprises quantifying the ganglioside GM3 level in a blood sample separated from a living body. More specifically, the method comprises the following steps (a) to (c): (a) separating a plasma or serum from the blood collected from a human body; (b) quantifying the ganglioside GM3 level in the plasma or serum; and (c) comparing the quantified ganglioside GM3 level to the average ganglioside GM3 level determined in blood samples from normal persons.
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Inventors:
INOKUCHI JINICHI (JP)
Application Number:
PCT/JP2007/061246
Publication Date:
December 06, 2007
Filing Date:
May 29, 2007
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
INOKUCHI JINICHI (JP)
INOKUCHI JINICHI (JP)
International Classes:
G01N30/88; G01N30/72; G01N30/90; G01N33/92
Foreign References:
| JP2005221293A | 2005-08-18 | |||
| JPS62187254A | 1987-08-15 | |||
| JP2005253434A | 2005-09-22 |
Other References:
TADASHI YAMASHITA ET AL.: "Enhanced insulin sensitivity in mice lacking ganglioside GM3", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 6, 18 March 2003 (2003-03-18), pages 3445 - 3449, XP002998994
INOGUCHI J. ET AL.: "Micro Domain Syndrome to shite no Insulin Teikosei to 2-Gata Tonyobyo", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 48, no. 8, 2003, pages 1179 - 1183, XP003019283
ZIEGLER R. ET AL.: "Multiple Target Anigens in Pre-Type I Diabetes: Implicatins for Prediction", HORMONE RESEARCH, vol. 33, no. 2/4, August 1990 (1990-08-01), pages 144 - 151, XP003019284
INOKUCHI J.: "Micro Domain Byo to shite no Insulin Teikosei: Ganglioside GM3 no Kan'yo", DAI 53 KAI THE SOCIETY OF POLYMER SCIENCE, JAPAN TORONKAI YOKOSHU CD-ROM, vol. 53, no. 2, 2004, pages 5386 - 5387 + ABSTR. NO. 2W14, XP003019285
INOKUCHI J. ET AL.: "2-Gata Tonyobyo no Insulin Teikosei ni Kakawaru Ganglioside GM3 no Kino", DAI 23 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAN YOSHISHU, 2002, pages 70 + ABSTR. NO. B3-10, XP003019286
GAVELLA M. ET AL.: "Lipid-Bound Sialic Acid in Diabetes", HORM. METABOL. RES., vol. 21, no. 5, 1989, pages 280 - 281, XP003019287
DONG HOON KWAK ET AL.: "Decreases of ganglioside GM3 in streptozotocin-induced diabetic glomeruli of rats", LIFE SCIENCES, vol. 72, no. 17, 14 March 2003 (2003-03-14), pages 1997 - 2006, XP003019288
See also references of EP 2026067A4
SCIENCE, vol. 302, no. 5648, 14 November 2003 (2003-11-14), pages 1223 - 7
TAGAMI ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 3085 - 3092
KABAYAMA ET AL., GLYCOBIOLOGY, vol. 15, 2005, pages 21 - 29
ARCH. BIOCHEM. BIOPHYS., vol. 238, 1985, pages 388 - 400
EUR. J. BIOCHEM., vol. 181, pages 657 - 662
SERA ET AL., J. NEUROLOGICAL SCIENCES, vol. 52, 1982, pages 143 - 148
J. CLIN. LAB. ANAL., vol. 3, 1989, pages 301 - 306
BERGELSON, IMMUNOLOGY TODAY, vol. 16, 1995, pages 483 - 486
SENN ET AL., EUR. J. BIOCHEM., vol. 181, 1989, pages 657 - 662
TAKASHI KANNO; NOBUYOSHI MATSUDA: "Rinsho-Kensa-Gijutsu", IGAKU-SHOIN, LTD
LADISCH ET AL., ANAL. BIOCHEM., vol. 146, 1985, pages 220 - 231
METHODS IN ENZYMOLOGY, vol. 138, 1987, pages 300 - 306
INOGUCHI J. ET AL.: "Micro Domain Syndrome to shite no Insulin Teikosei to 2-Gata Tonyobyo", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 48, no. 8, 2003, pages 1179 - 1183, XP003019283
ZIEGLER R. ET AL.: "Multiple Target Anigens in Pre-Type I Diabetes: Implicatins for Prediction", HORMONE RESEARCH, vol. 33, no. 2/4, August 1990 (1990-08-01), pages 144 - 151, XP003019284
INOKUCHI J.: "Micro Domain Byo to shite no Insulin Teikosei: Ganglioside GM3 no Kan'yo", DAI 53 KAI THE SOCIETY OF POLYMER SCIENCE, JAPAN TORONKAI YOKOSHU CD-ROM, vol. 53, no. 2, 2004, pages 5386 - 5387 + ABSTR. NO. 2W14, XP003019285
INOKUCHI J. ET AL.: "2-Gata Tonyobyo no Insulin Teikosei ni Kakawaru Ganglioside GM3 no Kino", DAI 23 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAN YOSHISHU, 2002, pages 70 + ABSTR. NO. B3-10, XP003019286
GAVELLA M. ET AL.: "Lipid-Bound Sialic Acid in Diabetes", HORM. METABOL. RES., vol. 21, no. 5, 1989, pages 280 - 281, XP003019287
DONG HOON KWAK ET AL.: "Decreases of ganglioside GM3 in streptozotocin-induced diabetic glomeruli of rats", LIFE SCIENCES, vol. 72, no. 17, 14 March 2003 (2003-03-14), pages 1997 - 2006, XP003019288
See also references of EP 2026067A4
SCIENCE, vol. 302, no. 5648, 14 November 2003 (2003-11-14), pages 1223 - 7
TAGAMI ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 3085 - 3092
KABAYAMA ET AL., GLYCOBIOLOGY, vol. 15, 2005, pages 21 - 29
ARCH. BIOCHEM. BIOPHYS., vol. 238, 1985, pages 388 - 400
EUR. J. BIOCHEM., vol. 181, pages 657 - 662
SERA ET AL., J. NEUROLOGICAL SCIENCES, vol. 52, 1982, pages 143 - 148
J. CLIN. LAB. ANAL., vol. 3, 1989, pages 301 - 306
BERGELSON, IMMUNOLOGY TODAY, vol. 16, 1995, pages 483 - 486
SENN ET AL., EUR. J. BIOCHEM., vol. 181, 1989, pages 657 - 662
TAKASHI KANNO; NOBUYOSHI MATSUDA: "Rinsho-Kensa-Gijutsu", IGAKU-SHOIN, LTD
LADISCH ET AL., ANAL. BIOCHEM., vol. 146, 1985, pages 220 - 231
METHODS IN ENZYMOLOGY, vol. 138, 1987, pages 300 - 306
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (IKUBO & KATAYAMAFukuoka Bldg. 9th Fl.,8-7, Yaesu 2-chome, Chuo-ku, Tokyo 28, JP)
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