Title:
METHOD FOR DETECTION OF DNA DAMAGE USING Frag1 GENE OR GENE PRODUCT THEREOF AS MARKER
Document Type and Number:
WIPO Patent Application WO/2006/090679
Kind Code:
A1
Abstract:
Disclosed are a novel molecular marker which enables to detect a DNA damage or unscheduled replication of DNA which may directly cause a genetic change or the like, with high sensitivity, and the like. A method for detecting a DNA damage by using, as a marker, a Frag1 gene, a gene product of the gene or a phosphorylated product of the gene product or a cellular response associated with the gene or product in a sample; a method for screening for an exogenous stimulation involving any one of various carcinogenic substances including various DNA replication inhibitors, carcinogens and potential carcinogens or for an anti-cancerous agent; a method for testing or diagnosing a disease associated with the expression or activity of Frag1; a kit for use in these methods; and the like.
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Inventors:
ISHI HIDESHI (JP)
HURUKAWA YUSUKKE (JP)
HURUKAWA YUSUKKE (JP)
Application Number:
PCT/JP2006/303008
Publication Date:
August 31, 2006
Filing Date:
February 21, 2006
Export Citation:
Assignee:
TOHOKU TECHNO ARCH CO LTD (JP)
ISHI HIDESHI (JP)
HURUKAWA YUSUKKE (JP)
ISHI HIDESHI (JP)
HURUKAWA YUSUKKE (JP)
International Classes:
C12N15/09; A01K67/027; C07K16/18; C12N5/10; C12Q1/68
Domestic Patent References:
| WO2004066948A2 | 2004-08-12 |
Other References:
ISHII H. ET AL.: "Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis", PROC. NATL. ACAD. SCI. USA, vol. 102, no. 27, July 2005 (2005-07-01), pages 9655 - 9660, XP003000901
KOMATSU K. ET AL.: "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-XL and promotes apoptosis", NAT. CELL BIOL., vol. 2, no. 1, 2000, pages 1 - 6, XP003000902
ADAMS J.M. ET AL.: "The Bcl-2 protein family: arbiters of cell survival", SCIENCE, vol. 281, 1998, pages 1322 - 1326, XP002942581
KOMATSU K. ET AL.: "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-XL and promotes apoptosis", NAT. CELL BIOL., vol. 2, no. 1, 2000, pages 1 - 6, XP003000902
ADAMS J.M. ET AL.: "The Bcl-2 protein family: arbiters of cell survival", SCIENCE, vol. 281, 1998, pages 1322 - 1326, XP002942581
Attorney, Agent or Firm:
Abe, Masahiro (14-1 Maebara-nishi 2-chom, Funabashi-shi Chiba 25, JP)
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