Title:
METHOD OF DETERMINING ABSOLUTE CONFIGURATION OF CHIRAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2001/040774
Kind Code:
A1
Abstract:
A novel general-purpose method of precisely and easily determining the absolute configuration of a chiral compound which can have various kinds of basic groups bonded. The method uses a metal porphyrin having a structure which comprises a porphyrin dimer crosslinked with a carbon chain and in which one of the two porphyrin rings has a substituent bulkier than an ethyl group and bonded to at least one of the second peripheral carbon atoms from the carbon atom at the crosslink with the carbon chain. In this method, either a chiral compound having an asymmetric carbon atom having, bonded thereto, a basic group capable of coordinating to the metal of the other porphyrin ring of the dimer structure of the metal porphyrin or a chiral compound having an asymmetric carbon atom adjacent to a carbon atom having the basic group bonded thereto is coordinated to the metal porphyrin. The resultant coordination compound is analyzed by spectrophotometry based on circular dichroism to determine the absolute configuration of the chiral compound based on the symbol of a Cotton effect.
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Inventors:
INOUE YOSHIHISA (JP)
BOROVKOV VICTOR (JP)
LINTULUOTO JUHA (JP)
BOROVKOV VICTOR (JP)
LINTULUOTO JUHA (JP)
Application Number:
PCT/JP2000/008559
Publication Date:
June 07, 2001
Filing Date:
December 04, 2000
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
INOUE YOSHIHISA (JP)
BOROVKOV VICTOR (JP)
LINTULUOTO JUHA (JP)
INOUE YOSHIHISA (JP)
BOROVKOV VICTOR (JP)
LINTULUOTO JUHA (JP)
International Classes:
C07D487/22; C09B47/00; (IPC1-7): G01N21/19; G01N21/77; C07D487/22; C09B47/00
Foreign References:
| JPH1029993A | 1998-02-03 | |||
| JPH09255682A | 1997-09-30 | |||
| JPH02237939A | 1990-09-20 |
Other References:
RICKMAN B.H. ET AL, TETRAHEDRON, vol. 54, 1998, pages 5041 - 5064, XP002937086
HAYASHI T. ET AL, TETRAHEDRON LETTERS, vol. 38, no. 9, 1997, pages 1603 - 1606, XP002937087
LIU H.-Y. ET AL, CHEM. COMMUN., 1997, pages 1575 - 1576, XP002937088
TAKEUCHI M. ET AL, CHEM. COMMUN., 1996, pages 1867 - 1868, XP002937089
BOROVKOV V.V. ET AL, J. AM. CHEM. SOC., vol. 122, no. 18, 2000, pages 4403 - 4407, XP002937090
BOROVKOV V.V. ET AL, ORG. LETT., vol. 2, no. 11, 2000, pages 1565 - 1568, XP002937091
MANYU SEIYAKU K.K. SENDAI SYMPOSIUM YOUSHISHUU, vol. 9, 1998, pages 23 - 25, XP002937092
See also references of EP 1235065A4
HAYASHI T. ET AL, TETRAHEDRON LETTERS, vol. 38, no. 9, 1997, pages 1603 - 1606, XP002937087
LIU H.-Y. ET AL, CHEM. COMMUN., 1997, pages 1575 - 1576, XP002937088
TAKEUCHI M. ET AL, CHEM. COMMUN., 1996, pages 1867 - 1868, XP002937089
BOROVKOV V.V. ET AL, J. AM. CHEM. SOC., vol. 122, no. 18, 2000, pages 4403 - 4407, XP002937090
BOROVKOV V.V. ET AL, ORG. LETT., vol. 2, no. 11, 2000, pages 1565 - 1568, XP002937091
MANYU SEIYAKU K.K. SENDAI SYMPOSIUM YOUSHISHUU, vol. 9, 1998, pages 23 - 25, XP002937092
See also references of EP 1235065A4
Attorney, Agent or Firm:
Saegusa, Eiji (Doshomachi Chuo-ku, Osaka-shi Osaka, JP)
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