Title:
METHOD FOR DETERMINING THE ACTIVITY OF AUTOIMMUNE DISEASES AND KIT
Document Type and Number:
WIPO Patent Application WO/2018/087416
Kind Code:
A3
Abstract:
The invention relates to a method for determining the activity level of autoimmune diseases, comprising: a) providing a biological sample; b) determining the level of the TßRII-A, TßRII-B and TßRII-Se isoforms in the biological sample; c) calculating the activity level, measuring the ratio between the level of TßRII-Se and the level of the sum of TßRII-A and TßRII- B. The level of the isoforms can be measured, with detection of the polypeptides of said isoforms or the mRNA of the isoforms in the isolated circulating blood mononuclear cells, for example using RT-qPCR.
Inventors:
VELASCO ZAMORA BENITO JORGE (ES)
DEWEY RICARDO ALFREDO (AR)
CARREA ALEJANDRA (AR)
PERONE MARCELO JAVIER (AR)
PREISEGGER MATÍAS ADÁN (AR)
DEWEY RICARDO ALFREDO (AR)
CARREA ALEJANDRA (AR)
PERONE MARCELO JAVIER (AR)
PREISEGGER MATÍAS ADÁN (AR)
Application Number:
PCT/ES2017/070752
Publication Date:
December 13, 2018
Filing Date:
November 14, 2017
Export Citation:
Assignee:
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN CONICET (AR)
FUND ARTICULAR (AR)
VELASCO ZAMORA BENITO JORGE (ES)
FUND ARTICULAR (AR)
VELASCO ZAMORA BENITO JORGE (ES)
International Classes:
G01N33/564
Domestic Patent References:
| WO2015095628A1 | 2015-06-25 |
Foreign References:
| AR093466A1 | 2015-06-10 |
Other References:
TANIA M. RODRÍGUEZ ET AL: "Effect of TGF-[beta]1 Stimulation on the Secretome of Human Adipose-Derived Mesenchymal Stromal Cells : TGF-[beta]1 Effect on Adipose-Derived MSC Secretome", STEM CELLS TRANSLATIONAL MEDICINE, vol. 4, no. 8, 29 May 2015 (2015-05-29), pages 894 - 898, XP055513402, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0012
ALEJANDRA CARREA: "Estudio de variantes de splicing del receptor tipo II de TGFbeta (TbetaRII) en células humanas y evaluación de su utilidad como biomarcadores de artritis reumatoidea", August 2013 (2013-08-01), UNIVERSIDAD NACIONAL DE LA PLATA; FACULTAD DE CIENCIAS EXACTAS; DEPARTAMENTO DE CIENCIAS BIOLÓGICAS, AR, pages 1 - 129, XP055513393, Retrieved from the Internet
ALEJANDRA CARREA: "Estudio de variantes de splicing del receptor tipo II de TGFbeta (TbetaRII) en células humanas y evaluación de su utilidad como biomarcadores de artritis reumatoidea", August 2013 (2013-08-01), UNIVERSIDAD NACIONAL DE LA PLATA; FACULTAD DE CIENCIAS EXACTAS; DEPARTAMENTO DE CIENCIAS BIOLÓGICAS, AR, pages 1 - 129, XP055513393, Retrieved from the Internet
Attorney, Agent or Firm:
SALIS, Eli (ES)
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