Title:
METHOD FOR DETERMINING AGE INDEPENDENTLY OF SEX
Document Type and Number:
WIPO Patent Application WO/2014/068092
Kind Code:
A3
Abstract:
The invention relates to a method for determining the aging condition of a subject. The method makes it possible to make conclusions about the age of a subject and conditions of the subject associated with the age - including independently of the sex - on the basis of certain nucleic acids or proteins and the expression level thereof. The invention further relates to a group of genes, the expression level of which depends on the aging condition of the particular subject - including independently of the sex. The invention further relates to the determination of the expression level of the genes and the use of the corresponding expression levels to determine aging conditions. The invention further relates to devices, in particular arrays and chips, that can be used to determine the aging condition of a subject.
Inventors:
MAKRANTONAKI EUGENIA (DE)
ZOUBOULIS CHRISTOS C (DE)
ADJAYE JAMES (DE)
ZOUBOULIS CHRISTOS C (DE)
ADJAYE JAMES (DE)
Application Number:
PCT/EP2013/072878
Publication Date:
June 26, 2014
Filing Date:
November 01, 2013
Export Citation:
Assignee:
MAKRANTONAKI EUGENIA (DE)
ZOUBOULIS CHRISTOS C (DE)
ZOUBOULIS CHRISTOS C (DE)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2001053472A2 | 2001-07-26 | |||
| WO1996013610A2 | 1996-05-09 | |||
| WO2002004662A1 | 2002-01-17 | |||
| WO2006036943A2 | 2006-04-06 | |||
| WO2002074911A2 | 2002-09-26 |
Foreign References:
| US20120040855A1 | 2012-02-16 |
Other References:
JACOB M ZAHN ET AL: "AGEMAP: a gene expression database for aging in mice", PLOS GENETICS, PLOS, vol. 3, no. 11, 30 November 2007 (2007-11-30), pages 2326 - 2337, XP008153921, ISSN: 1533-7390, DOI: 10.1371/JOURNAL.PGEN.0030201
WEINDRUCH R ET AL: "Gene expression profiling of aging using DNA microarrays", MECHANISMS OF AGEING AND DEVELOPMENT, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 123, 1 January 2002 (2002-01-01), pages 177 - 193, XP002304151, ISSN: 0047-6374, DOI: 10.1016/S0047-6374(01)00344-X
THORE C BRINK ET AL: "Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging", BIOGERONTOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 10, no. 5, 23 November 2008 (2008-11-23), pages 549 - 564, XP019727542, ISSN: 1573-6768
LEE C-K ET AL: "Gene expression profile of aging and its retardation by caloric restriction", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 285, no. 5432, 27 August 1999 (1999-08-27), pages 1390 - 1393, XP002341761, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.285.5432.1390
WEINDRUCH R ET AL: "Gene expression profiling of aging using DNA microarrays", MECHANISMS OF AGEING AND DEVELOPMENT, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 123, 1 January 2002 (2002-01-01), pages 177 - 193, XP002304151, ISSN: 0047-6374, DOI: 10.1016/S0047-6374(01)00344-X
THORE C BRINK ET AL: "Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging", BIOGERONTOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 10, no. 5, 23 November 2008 (2008-11-23), pages 549 - 564, XP019727542, ISSN: 1573-6768
LEE C-K ET AL: "Gene expression profile of aging and its retardation by caloric restriction", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 285, no. 5432, 27 August 1999 (1999-08-27), pages 1390 - 1393, XP002341761, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.285.5432.1390
Attorney, Agent or Firm:
FUCHS PATENTANWÄLTE (Frankfurt am Main, DE)
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