Title:
METHOD FOR DETERMINING DECREASE IN FUNCTIONS OF HIPPOCAMPUS BY USING CORRELATION BETWEEN MICRO RNA AND NMDA RECEPTOR, METHOD FOR INHIBITING DECREASE IN FUNCTIONS, AND METHOD FOR SCREENING FOR INHIBITORS OF DECREASE IN FUNCTIONS
Document Type and Number:
WIPO Patent Application WO/2016/204562
Kind Code:
A1
Abstract:
The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.
Inventors:
KIM KEE TAE (KR)
NAM HONG GIL (KR)
NAM HONG GIL (KR)
Application Number:
PCT/KR2016/006465
Publication Date:
December 22, 2016
Filing Date:
June 17, 2016
Export Citation:
Assignee:
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
INST BASIC SCIENCE (KR)
INST BASIC SCIENCE (KR)
International Classes:
C12Q1/68; C12N15/113; G01N33/68
Domestic Patent References:
| WO2014169226A2 | 2014-10-16 |
Foreign References:
| US20120214688A1 | 2012-08-23 |
Other References:
KIM, K. ET AL.: "miRNA-mediated Regulation of Eph/ephrin Signaling plays a Role in Synaptic Plasticity Control in Aged Mouse Hippocampus", 2014 NEUROSCIENCE MEETING PLANNER, 18 November 2014 (2014-11-18), Washington
KIM, K. ET AL.: "miRNA-mediated Regulation of Eph/ephrin Signaling plays a Role in Synaptic Plasticity Control in Aged Mouse Hippocampus", 2014 SPRING CONFERENCE OF THE KOREAN SOCIETY FOR GERONTOLOGY AND THE 13TH KOREA - JAPAN GERONTOLOGIST JOINT MEETING, 19 June 2014 (2014-06-19)
GAO , R. ET AL.: "MiR-204 promotes Apoptosis in Oxidative Stress-induced Rat Schwann Cells by Suppressing Neuritin Expression", FEBS LETTERS, vol. 588, no. 17, 15 July 2014 (2014-07-15), pages 3225 - 3232, XP055339139
PAI, B. ET AL.: "NMDA Receptor-dependent Regulation of miRNA Expression and Association with Argonaute during LTP in Vivo", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, no. 285, 13 January 2014 (2014-01-13), pages 1 - 15, XP055339141
KIM, K. ET AL.: "miRNA-mediated Regulation of Eph/ephrin Signaling plays a Role in Synaptic Plasticity Control in Aged Mouse Hippocampus", 2014 SPRING CONFERENCE OF THE KOREAN SOCIETY FOR GERONTOLOGY AND THE 13TH KOREA - JAPAN GERONTOLOGIST JOINT MEETING, 19 June 2014 (2014-06-19)
GAO , R. ET AL.: "MiR-204 promotes Apoptosis in Oxidative Stress-induced Rat Schwann Cells by Suppressing Neuritin Expression", FEBS LETTERS, vol. 588, no. 17, 15 July 2014 (2014-07-15), pages 3225 - 3232, XP055339139
PAI, B. ET AL.: "NMDA Receptor-dependent Regulation of miRNA Expression and Association with Argonaute during LTP in Vivo", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, no. 285, 13 January 2014 (2014-01-13), pages 1 - 15, XP055339141
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 이룸리온 (KR)
특허법인 이룸리온 (KR)
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