Title:
METHOD FOR DETERMINING EFFECTIVENESS OF CANCER TREATMENT USING RET KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/234222
Kind Code:
A1
Abstract:
A method for determining effectiveness of a cancer treatment using a RET kinase inhibitor, the method comprising: a step for detecting, in a sample isolated from a subject, an amino acid mutation in a calmodulin-like motif of a RET protein; and a step for, if the amino acid mutation is detected in said step, determining that the cancer treatment using the RET kinase inhibitor is highly effective for the subject.
Inventors:
KOHNO TAKASHI (JP)
NAKAOKU TAKASHI (JP)
NAKAOKU TAKASHI (JP)
Application Number:
PCT/JP2023/019779
Publication Date:
December 07, 2023
Filing Date:
May 26, 2023
Export Citation:
Assignee:
NAT CANCER CT (JP)
International Classes:
A61P35/00; C12Q1/6827; C12Q1/6886; G01N33/574; C07K16/28; C12N15/12
Domestic Patent References:
| WO2013018882A1 | 2013-02-07 | |||
| WO2017155044A1 | 2017-09-14 |
Other References:
NAKAOKU, TAKASHI ET AL.: "RET Rearrangements and Mutations", GAN BUNSHI HYOTEKI CHIRYO = MOLECULAR TARGETING THERAPY FOR CANCER ENGINEERING, MEDIKARU REBYUSHA, JP, vol. 19, no. 1, 30 September 2021 (2021-09-30), JP , pages 89 - 93, XP009551383, ISSN: 1347-6955
WIRTH LORI J., SHERMAN ERIC, ROBINSON BRUCE, SOLOMON BENJAMIN, KANG HYUNSEOK, LORCH JOCHEN, WORDEN FRANCIS, BROSE MARCIA, PATEL JY: "Efficacy of Selpercatinib in RET -Altered Thyroid Cancers", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 383, no. 9, 27 August 2020 (2020-08-27), US , pages 825 - 835, XP093115869, ISSN: 0028-4793, DOI: 10.1056/NEJMoa2005651
TABATA JUNYA: "Promotion of Cancer Genome Treatments Based on Functional Genome Analysis of Variants of Unspecified Significance with Identified Kinase Genes", 2020 SENIOR RESEARCH FELLOW, RESEARCH REPORT, 1 January 2020 (2020-01-01), XP093115871
TABATA JUNYA, NAKAOKU TAKASHI, ARAKI MITSUGU, YOSHINO RYUNOSUKE, KOHSAKA SHINJI, OTSUKA AYAKA, IKEGAMI MASACHIKA, UI AYAKO, KANNO : "Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 82, no. 20, 17 October 2022 (2022-10-17), US, pages 3751 - 3762, XP093115872, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-22-0834
WIRTH LORI J., SHERMAN ERIC, ROBINSON BRUCE, SOLOMON BENJAMIN, KANG HYUNSEOK, LORCH JOCHEN, WORDEN FRANCIS, BROSE MARCIA, PATEL JY: "Efficacy of Selpercatinib in RET -Altered Thyroid Cancers", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 383, no. 9, 27 August 2020 (2020-08-27), US , pages 825 - 835, XP093115869, ISSN: 0028-4793, DOI: 10.1056/NEJMoa2005651
TABATA JUNYA: "Promotion of Cancer Genome Treatments Based on Functional Genome Analysis of Variants of Unspecified Significance with Identified Kinase Genes", 2020 SENIOR RESEARCH FELLOW, RESEARCH REPORT, 1 January 2020 (2020-01-01), XP093115871
TABATA JUNYA, NAKAOKU TAKASHI, ARAKI MITSUGU, YOSHINO RYUNOSUKE, KOHSAKA SHINJI, OTSUKA AYAKA, IKEGAMI MASACHIKA, UI AYAKO, KANNO : "Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 82, no. 20, 17 October 2022 (2022-10-17), US, pages 3751 - 3762, XP093115872, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-22-0834
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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