Title:
METHOD FOR DETERMINING LIQUID FLOW RATE, FRACTION COLLECTOR AND LIQUID CHROMATOGRAPHY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2021/248985
Kind Code:
A1
Abstract:
A method for determining a liquid flow rate in a liquid chromatography system. The liquid chromatography system sequentially comprises a fraction valve (210), a first sensor (220) and a second sensor (230) in a flow direction, a pipeline between the first sensor (220) and the second sensor (230) having a known volume of the pipeline between the sensors. The method comprises: step A: emptying a pipeline between a liquid discharge port of a fraction valve (210) and a first sensor (220); step B: guiding a liquid flow from the liquid discharge port of the fraction valve (210) to a pipeline at a position where the first sensor (220) and a second sensor (230) are located; and step C: determining the flow rate of the liquid flow on the basis of a time difference between a first moment when the first sensor (220) detects a liquid-gas interface where the liquid flow interfaces with a gas and a second moment when the second sensor (230) detects the liquid-gas interface, and the volume of the pipeline between the sensors. Further provided is a fraction collector. The accuracy of flow rate measurement and the efficiency of fraction collection can be greatly improved by the liquid-gas interfaces provided by the liquid flow passing through the emptied liquid discharge pipeline.
Inventors:
WANG HONGFANG (CN)
LI GANG (CN)
FAN KUN (CN)
GONG CHAO (CN)
LI GANG (CN)
FAN KUN (CN)
GONG CHAO (CN)
Application Number:
PCT/CN2021/083669
Publication Date:
December 16, 2021
Filing Date:
March 29, 2021
Export Citation:
Assignee:
THERMO FISHER SCIENT SHANGHAI INSTRUMENTS CO LTD (CN)
THERMO FISHER SCIENT SUZHOU INSTRUMENTS CO LTD (CN)
THERMO FISHER SCIENT SUZHOU INSTRUMENTS CO LTD (CN)
International Classes:
G01N30/02; G01F1/64; G01F1/708; G01N30/80
Foreign References:
| CN111505173A | 2020-08-07 | |||
| US20160131617A1 | 2016-05-12 | |||
| US20160069720A1 | 2016-03-10 | |||
| JP2014102164A | 2014-06-05 | |||
| JPH02150768A | 1990-06-11 | |||
| CN109765334A | 2019-05-17 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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