Title:
METHOD FOR DETERMINING LOCAL TOXICITY OF SUBSTANCES
Document Type and Number:
WIPO Patent Application WO/2010/111977
Kind Code:
A3
Abstract:
The invention relates to a method of testing the local toxicity of a substance, characterized in that a cornea of an animal is exposed to the substance and the change in the corneal thickness is measured, and optionally also the change in the corneal light absorption or light transmission properties is measured. The change in the cornea thickness can be measured by a pachymeter, the change in the corneal absorption or transmission properties can be measured pectrophotometrically. The invention further relates to an insert to a cuvette for the spectrophotometric measurement. ˙
Inventors:
CEJKOVA JITKA (CZ)
CEJKA CESTMIR (CZ)
MICHALEK JIRI (CZ)
SIRC JAKUB (CZ)
CEJKA CESTMIR (CZ)
MICHALEK JIRI (CZ)
SIRC JAKUB (CZ)
Application Number:
PCT/CZ2010/000034
Publication Date:
November 25, 2010
Filing Date:
March 29, 2010
Export Citation:
Assignee:
USTAV EX MEDICINY AV CR V V I (CZ)
USTAV MAKROMOLEKULARNI CHEMIE (CZ)
CEJKOVA JITKA (CZ)
CEJKA CESTMIR (CZ)
MICHALEK JIRI (CZ)
SIRC JAKUB (CZ)
USTAV MAKROMOLEKULARNI CHEMIE (CZ)
CEJKOVA JITKA (CZ)
CEJKA CESTMIR (CZ)
MICHALEK JIRI (CZ)
SIRC JAKUB (CZ)
International Classes:
A61F9/01; G01N21/03; B01L3/00; C12M3/00; G01J3/02; G01N21/62; G01N21/63; G01N21/84; G02B21/34
Domestic Patent References:
| WO2003052391A1 | 2003-06-26 |
Foreign References:
| GB1188613A | 1970-04-22 | |||
| US5833923A | 1998-11-10 | |||
| RU2102069C1 | 1998-01-20 | |||
| RU2207828C2 | 2003-07-10 | |||
| GB1188613A | 1970-04-22 | |||
| SU1617377A1 | 1990-12-30 |
Other References:
DENOYER A. ET AL: "Very-high-frequency ultrasound corneal imaging as a new tool for early diagnosis of ocular surface toxicity in rabbits treated with a preserved glaucoma drug", OPHTHALMIC RES., vol. 40, no. 6, October 2008 (2008-10-01), pages 298 - 308, Retrieved from the Internet
Attorney, Agent or Firm:
HARTVICHOVA, Katerina (Na Belidle 3, Praha 5, CZ)
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