Title:
METHOD FOR DETERMINING POSSIBILITY OF ONSET OF COLON CANCER
Document Type and Number:
WIPO Patent Application WO/2018/008153
Kind Code:
A1
Abstract:
The present invention is a method for determining the possibility of the onset of colon cancer in human ulcerative colitis patients, wherein the method for determining the possibility of onset of colon cancer includes a measurement step for measuring the methylation rate of one or more CpG sites selected from the group consisting of CpG sites in base sequences represented by SEQ ID NOS: 1-80 in DNA recovered from a biological sample collected from a human ulcerative colitis patient, and a determination step for determining the possibility of onset of colon cancer in the human ulcerative colitis patient on the basis of the methylation rate measured in the measurement step and a preset reference value or preset multivariate discriminant.
Inventors:
KUSUNOKI MASATO (JP)
TOIYAMA YUJI (JP)
TANAKA KOJI (JP)
ARAKI TOSHIMITSU (JP)
MITSUI AKIRA (JP)
TAKEHANA KENJI (JP)
UMEZAWA TSUTOMU (JP)
TOIYAMA YUJI (JP)
TANAKA KOJI (JP)
ARAKI TOSHIMITSU (JP)
MITSUI AKIRA (JP)
TAKEHANA KENJI (JP)
UMEZAWA TSUTOMU (JP)
Application Number:
PCT/JP2016/070330
Publication Date:
January 11, 2018
Filing Date:
July 08, 2016
Export Citation:
Assignee:
HANUMAT CO LTD (JP)
EA PHARMA CO LTD (JP)
EA PHARMA CO LTD (JP)
International Classes:
C12Q1/68; C12N15/09; G01N33/48; G01N33/50
Domestic Patent References:
| WO2014046197A1 | 2014-03-27 | |||
| WO2011002029A1 | 2011-01-06 | |||
| WO2004082488A1 | 2004-09-30 |
Foreign References:
| JP2015006164A | 2015-01-15 | |||
| JP2014140377A | 2014-08-07 | |||
| EP2891720A1 | 2015-07-08 | |||
| JP2012200414A | 2012-10-22 | |||
| JPH0819548A | 1996-01-23 |
Other References:
KIBRIYA, MUHAMMAD G. ET AL.: "A genome-wide DNA methylation study in colorectal carcinoma", BMC MEDICAL GENOMICS, vol. 4, no. 1, 2011, pages 50, XP021104259, DOI: 10.1186/1755-8794-4-50
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
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